Proanthocyanidins regulate the Nrf2/ARE signaling pathway and protect neurons from cypermethrin-induced oxidative stress and apoptosis

L Zhou, J Chang, W Zhao, Y Gao - Pesticide Biochemistry and Physiology, 2021 - Elsevier
Cypermethrin, a type II pyrethroid pesticide, is one of the most widely used pesticides in
agricultural and in household settings. The toxic effects of cypermethrin are a matter of …

Cypermethrin-induced cortical neurons apoptosis via the Nrf2/ARE signaling pathway

L Zhou, M Zhou, H Tan, M Xiao - Pesticide biochemistry and physiology, 2020 - Elsevier
Pesticide residue is a common problem worldwide. Cypermethrin is a type II pyrethroid
pesticide that has been widely used in recent years. It has become a widespread residual …

Plumbagin, a novel Nrf2/ARE activator, protects against cerebral ischemia

TG Son, S Camandola, TV Arumugam… - Journal of …, 2010 - Wiley Online Library
J. Neurochem.(2010) 112, 1316–1326. Abstract Many phytochemicals function as noxious
agents that protect plants against insects and other damaging organisms. However, at …

Procyanidin B2 protects neurons from cypermethrin-induced oxidative stress through the P13K/Akt/Nrf2 signaling pathway

L Zhou, J Chang, Y Gao, C Wang - Nan Fang yi ke da xue xue bao …, 2021 - europepmc.org
Objective To explore whether procyanidin B2 (PCB2) regulates the P13K/Akt/Nrf2 signaling
pathway to protect neurons from oxidative stress induced by cypermethrin (CYP). Methods …

Neuroprotective efficacy of naringin on 3-nitropropionic acid-induced mitochondrial dysfunction through the modulation of Nrf2 signaling pathway in PC12 cells

G Kulasekaran, S Ganapasam - Molecular and Cellular Biochemistry, 2015 - Springer
Oxidative stress and mitochondrial dysfunction are implicated in neuronal apoptosis
associated with Huntington's disease. Naringin is the flavanone present in grapefruit and …

[HTML][HTML] Neuroprotective effects of proanthocyanidins, natural flavonoids derived from plants, on rotenone-induced oxidative stress and apoptotic cell death in human …

J Ma, SS Gao, HJ Yang, M Wang, BF Cheng… - Frontiers in …, 2018 - frontiersin.org
Proanthocyanidins (PA) are natural flavonoids widely present in many vegetables, fruits,
nuts and seeds, and especially in grape seed. In the present study, we examined the …

[HTML][HTML] Neuroprotection against 6-OHDA toxicity in PC12 cells and mice through the Nrf2 pathway by a sesquiterpenoid from Tussilago farfara

J Lee, K Song, E Huh, MS Oh, YS Kim - Redox biology, 2018 - Elsevier
Oxidative stress plays a key role in neurodegenerative diseases such as Alzheimer's and
Parkinson's diseases. Therefore, the nuclear factor-E2-related factor 2 (Nrf2), a key regulator …

Oat polyphenol avenanthramide-2c confers protection from oxidative stress by regulating the Nrf2-ARE signaling pathway in PC12 cells

Y Hou, S Peng, Z Song, F Bai, X Li, J Fang - Archives of biochemistry and …, 2021 - Elsevier
Accumulating evidence has demonstrated that cellular antioxidant systems play essential
roles in retarding oxidative stress-related diseases, such as Parkinson's disease. Because …

Pinostrobin exerts neuroprotective actions in neurotoxin-induced Parkinson's disease models through Nrf2 induction

C Li, B Tang, Y Feng, F Tang… - Journal of agricultural …, 2018 - ACS Publications
The aim of the present study was to assess the neuroprotective effects of pinostrobin (PSB),
a dietary bioflavonoid, and its underlying mechanisms in neurotoxin-induced Parkinson's …

Naphthazarin protects against glutamate-induced neuronal death via activation of the Nrf2/ARE pathway

TG Son, EM Kawamoto, QS Yu, NH Greig… - Biochemical and …, 2013 - Elsevier
Nuclear factor E2-related factor 2 (Nrf2)/antioxidant response element (ARE) pathway is an
important cellular stress response pathway involved in neuroprotection. We previously …