Insulin resistance is characteristic of obesity, type 2 diabetes, and components of the
cardiometabolic syndrome, including hypertension and dyslipidemia, that collectively …

Type 2 diabetes mellitus (T2DM) has been related to alterations of oxidative metabolism in
insulin-responsive tissues. Overt T2DM can present with acquired or inherited reductions of …

Insulin resistance precedes and predicts the onset of type 2 diabetes (T2D) in susceptible
humans, underscoring its important role in the complex pathogenesis of this disease. Insulin …

Abundant evidence has been accumulated to suggest that mitochondrial dysfunction is
associated with type 2 diabetes. Research findings from this and other laboratories have …

Insulin resistance is a key defect associated with obesity and type-2 diabetes. The precise
factors that lead to insulin resistance have not been elucidated fully, but there is a strong …

The specific cellular underpinnings or mechanisms of insulin resistance (IR) are not clear.
Here I present evidence to support a causal association between mitochondrial energetics …

Insulin resistance (IR) is fundamental to the development of type 2 diabetes (T2D) and is
present in most prediabetic (preDM) individuals. Insulin resistance has both heritable and …

Background The prevalence of type 2 diabetes is rapidly increasing world-wide and insulin
resistance is central to the aetiology of this disease. The biology underpinning the …

Mitochondrial function refers to a broad spectrum of features such as resting mitochondrial
activity,(sub) maximal oxidative phosphorylation capacity (OXPHOS), and mitochondrial …

Diabetes profoundly alters fuel metabolism; both insulin deficiency and insulin resistance
are characterized by inefficient mitochondrial coupling and excessive production of reactive …