Genetic and genomic approaches have implicated hundreds of genetic loci in
neurodevelopmental disorders and neurodegeneration, but mechanistic understanding …

Advances in genetics and genomics have fuelled a revolution in discovery-based, or
hypothesis-generating, research that provides a powerful complement to the more directly …

Neurodegenerative diseases are rarely caused by a mutation in a single gene but rather
influenced by a combination of genetic, epigenetic and environmental factors. Emerging …

Classical biological methods involving analyses of one or several genes have been the
mainstay for studying the pathogenesis of neurodegenerative disorders. However, it has …

Over the past five years the field of neurogenetics has yielded a wealth of data that have
facilitated a much greater understanding of the aetiology of many neurological diseases …

The development and function of our brain are governed by a genetic blueprint, which
reflects dynamic changes over the history of evolution. Recent progress in genetics and …

Gene networks have yielded numerous neurobiological insights, yet an integrated view
across brain regions is lacking. We leverage RNA sequencing in 864 samples representing …

Genetic determinants of cognition are poorly characterized, and their relationship to genes
that confer risk for neurodevelopmental disease is unclear. Here we performed a systems …

Complex diseases are caused by perturbations of biological networks. Genetic analysis
approaches focused on individual genetic determinants are unlikely to characterize the …

Recent advances in molecular biology, neurobiology, genetics, and imaging have
demonstrated important insights about the nature of neurological diseases. However, a …