Imbalance of the excitatory neurotransmitter glutamate and of the inhibitory neurotransmitter
GABA is one of several causes of seizures. ATP has also been implicated in epilepsy …

Abstract Pannexin-1 (Panx1) expression is raised in several animal seizure models and in
resected human epileptic brain tissue, suggesting relevance to epilepsy. Multiple factors that …

Epilepsies are characterized by recurrent seizures, which disrupt normal brain function.
Alterations in neuronal excitability and excitation-inhibition balance have been shown to …

Abstract Pannexin‐1 (Panx1) is a large pore membrane channel with unique conduction
properties ranging from non‐selective ion permeability to the extracellular release of …

Astroglial release of molecules is thought to actively modulate neuronal activity, but the
nature, release pathway, and cellular targets of these neuroactive molecules are still …

Pannexin 1 (Panx1) represents a class of vertebrate membrane channels, bearing
significant sequence homology with the invertebrate gap junction proteins, the innexins and …

Pannexin 1 (Panx1) channels are transmembrane proteins that release adenosine
triphosphate and play an important role in intercellular communication. They are widely …

Pannexin1 (Panx1) channels release cytosolic ATP in response to signaling pathways.
Panx1 is highly expressed in the central nervous system. We used four antibodies with …

Synaptic loss induced by soluble oligomeric forms of the amyloid β peptide (sAβos) is one of
the earliest events in Alzheimer's disease (AD) and is thought to be the major cause of the …

Pannexin-1 (Panx1) plays a role in the release of ATP and glutamate in neurons and
astrocytes. Panx1 can be opened at the resting membrane potential by extracellular ATP via …