Use of surfactant-based amorphous solid dispersions for BDDCS class II drugs to enhance oral bioavailability: A case report of resveratrol
X Jia, J Chen, H Cheng, X Pan, Y Ke, T Fu… - International Journal of …, 2023 - Elsevier
This paper aimed to improve in vitro dissolution/solubility as well as inhibit intestinal
metabolism and thus enhance oral bioavailability for a BDDCS class II drug by constructing …
metabolism and thus enhance oral bioavailability for a BDDCS class II drug by constructing …
Effects of dendrimer-like biopolymers on physical stability of amorphous solid dispersions and drug permeability across Caco-2 cell monolayers
M Lavan, G Knipp - AAPS PharmSciTech, 2018 - Springer
The potential applications of dendrimer-like biopolymers (DLB) as stabilizing excipients for
amorphous solid dispersion (ASD) of niclosamide, celecoxib, and resveratrol were …
amorphous solid dispersion (ASD) of niclosamide, celecoxib, and resveratrol were …
[HTML][HTML] Mechanistic insights into effect of surfactants on oral bioavailability of amorphous solid dispersions
A Schittny, S Philipp-Bauer, P Detampel… - Journal of Controlled …, 2020 - Elsevier
Drug delivery of poorly soluble drugs in form amorphous solid dispersions (ASDs) is an
appealing method to increase in vivo bioavailability. For rational formulation design, a …
appealing method to increase in vivo bioavailability. For rational formulation design, a …
Effervescence-induced amorphous solid dispersions with improved drug solubility and dissolution
M Pisay, DL Yarlagadda, SKA Vullendula… - Pharmaceutical …, 2023 - Taylor & Francis
The current study aimed to investigate drug carrier miscibility in pharmaceutical solid
dispersions (SD) and include the effervescent system, ie Effervescence-induced amorphous …
dispersions (SD) and include the effervescent system, ie Effervescence-induced amorphous …
Effect of amorphous phase separation and crystallization on the in vitro and in vivo performance of an amorphous solid dispersion
In this study, the performance of phase separated and crystallized amorphous solid
dispersions (ASDs) was evaluated by non-sink in vitro dissolution testing in fasted-state …
dispersions (ASDs) was evaluated by non-sink in vitro dissolution testing in fasted-state …
Third-Generation Solid Dispersion Through Lyophilization Enhanced Oral Bioavailability of Resveratrol
H Almeida, B Ferreira… - ACS Pharmacology & …, 2024 - ACS Publications
Resveratrol (RES) is a biopharmaceutical classification system (BCS) class II compound
with low solubility and high permeability. Several strategies have been explored to …
with low solubility and high permeability. Several strategies have been explored to …
Development of controlled release amorphous solid dispersions (CRASD) using polyvinyl acetate-based release retarding materials: Effect of dosage form design
JA Lugtu-Pe, A Ghaffari, K Chen, A Kane… - European Journal of …, 2018 - Elsevier
The amorphous solid dispersion (ASD) technique has been employed to formulate poorly-
soluble drugs, however, development of solid dosage forms with ASD is challenging due to …
soluble drugs, however, development of solid dosage forms with ASD is challenging due to …
[HTML][HTML] Combining lipid based drug delivery and amorphous solid dispersions for improved oral drug absorption of a poorly water-soluble drug
GI Nora, R Venkatasubramanian, S Strindberg… - Journal of Controlled …, 2022 - Elsevier
Two widely applied enabling drug delivery approaches, self-nanoemulsifying drug delivery
systems (SNEDDS) and amorphous solid dispersions (ASD), were combined, with the aim of …
systems (SNEDDS) and amorphous solid dispersions (ASD), were combined, with the aim of …
Impact of gastric pH variations on the release of amorphous solid dispersion formulations containing a weakly basic drug and enteric polymers
Enteric polymers are widely used in amorphous solid dispersion (ASD) formulations. The
aim of the current study was to explore ASD failure mechanisms across a wide range of pH …
aim of the current study was to explore ASD failure mechanisms across a wide range of pH …
Exploration of supersaturable lacidipine ternary amorphous solid dispersion for enhanced dissolution and in vivo absorption
J Guan, L Jin, Q Liu, H Xu, H Wu, X Zhang… - European Journal of …, 2019 - Elsevier
Amorphous solid dispersion stands out among different formulation strategies for the
improvement of dissolution rate and bioavailability via generating supersaturated drug …
improvement of dissolution rate and bioavailability via generating supersaturated drug …