Use of surfactant-based amorphous solid dispersions for BDDCS class II drugs to enhance oral bioavailability: A case report of resveratrol

X Jia, J Chen, H Cheng, X Pan, Y Ke, T Fu… - International Journal of …, 2023 - Elsevier
This paper aimed to improve in vitro dissolution/solubility as well as inhibit intestinal
metabolism and thus enhance oral bioavailability for a BDDCS class II drug by constructing …

Effects of dendrimer-like biopolymers on physical stability of amorphous solid dispersions and drug permeability across Caco-2 cell monolayers

M Lavan, G Knipp - AAPS PharmSciTech, 2018 - Springer
The potential applications of dendrimer-like biopolymers (DLB) as stabilizing excipients for
amorphous solid dispersion (ASD) of niclosamide, celecoxib, and resveratrol were …

[HTML][HTML] Mechanistic insights into effect of surfactants on oral bioavailability of amorphous solid dispersions

A Schittny, S Philipp-Bauer, P Detampel… - Journal of Controlled …, 2020 - Elsevier
Drug delivery of poorly soluble drugs in form amorphous solid dispersions (ASDs) is an
appealing method to increase in vivo bioavailability. For rational formulation design, a …

Effervescence-induced amorphous solid dispersions with improved drug solubility and dissolution

M Pisay, DL Yarlagadda, SKA Vullendula… - Pharmaceutical …, 2023 - Taylor & Francis
The current study aimed to investigate drug carrier miscibility in pharmaceutical solid
dispersions (SD) and include the effervescent system, ie Effervescence-induced amorphous …

Effect of amorphous phase separation and crystallization on the in vitro and in vivo performance of an amorphous solid dispersion

MM Knopp, J Wendelboe, R Holm, T Rades - European Journal of …, 2018 - Elsevier
In this study, the performance of phase separated and crystallized amorphous solid
dispersions (ASDs) was evaluated by non-sink in vitro dissolution testing in fasted-state …

Third-Generation Solid Dispersion Through Lyophilization Enhanced Oral Bioavailability of Resveratrol

H Almeida, B Ferreira… - ACS Pharmacology & …, 2024 - ACS Publications
Resveratrol (RES) is a biopharmaceutical classification system (BCS) class II compound
with low solubility and high permeability. Several strategies have been explored to …

Development of controlled release amorphous solid dispersions (CRASD) using polyvinyl acetate-based release retarding materials: Effect of dosage form design

JA Lugtu-Pe, A Ghaffari, K Chen, A Kane… - European Journal of …, 2018 - Elsevier
The amorphous solid dispersion (ASD) technique has been employed to formulate poorly-
soluble drugs, however, development of solid dosage forms with ASD is challenging due to …

[HTML][HTML] Combining lipid based drug delivery and amorphous solid dispersions for improved oral drug absorption of a poorly water-soluble drug

GI Nora, R Venkatasubramanian, S Strindberg… - Journal of Controlled …, 2022 - Elsevier
Two widely applied enabling drug delivery approaches, self-nanoemulsifying drug delivery
systems (SNEDDS) and amorphous solid dispersions (ASD), were combined, with the aim of …

Impact of gastric pH variations on the release of amorphous solid dispersion formulations containing a weakly basic drug and enteric polymers

HT Nguyen, T Van Duong, LS Taylor - Molecular Pharmaceutics, 2023 - ACS Publications
Enteric polymers are widely used in amorphous solid dispersion (ASD) formulations. The
aim of the current study was to explore ASD failure mechanisms across a wide range of pH …

Exploration of supersaturable lacidipine ternary amorphous solid dispersion for enhanced dissolution and in vivo absorption

J Guan, L Jin, Q Liu, H Xu, H Wu, X Zhang… - European Journal of …, 2019 - Elsevier
Amorphous solid dispersion stands out among different formulation strategies for the
improvement of dissolution rate and bioavailability via generating supersaturated drug …