BACKGROUND The hormone ghrelin and the adipocytokines leptin and adiponectin
participate in body weight regulation. In response to weight loss, ghrelin and adiponectin …

Background Anorexia, cachexia, and insulin resistance are commonly seen in patients with
cancer. Adipocyte-derived hormones or adipokines play a role in the regulation of appetite …

Background Cancer cachexia, a catabolic state characterized by weight loss, occurs
frequently in patients with terminal-stage neoplastic diseases. Gastrointestinal hormones …

AIM: To investigate the roles of the adipocytokines, ghrelin and leptin in gastric cancer
cachexia. METHODS: Resistin, ghrelin, leptin, adiponectin, insulin and insulin-like growth …

We investigated the role of fasting hormones and pro-inflammatory cytokines in cancer
patients. Hormones (ghrelin, adiponectin, and leptin) and cytokines (TNF-α, IFN-γ, and IL-6) …

Cachexia, a paraneoplastic syndrome markedly associated with worsened prognosis in
cancer patients, provokes profound wasting of both lean and adipose mass in an …

Background Cachexia may occur in 40% of cancer patients, representing the major cause of
death in more than 20% of them. The aim of this study was to investigate the role of leptin …

Anorexia and weight loss are negative prognostic factors in patients with cancer. Although
total ghrelin levels are increased in energy-negative states, levels of the biologically active …

Ghrelin is a gastrointestinal peptide that stimulates food intake and growth hormone (GH)
secretion. We studied the biosynthesis and secretion of ghrelin in a cancer cachexia mouse …

Purpose: Ghrelin, a novel growth hormone-releasing peptide, has been shown to cause a
positive energy balance by stimulating food intake and inducing adiposity. We sought to …