[HTML][HTML] Genetic landscape and emerging therapies in uveal melanoma

RS Seedor, M Orloff, T Sato - Cancers, 2021 - mdpi.com
Simple Summary Uveal melanoma is the most common primary intraocular malignancy in
adults. Unfortunately, metastasis develops in up to 50% of cases and outcomes are poor for …

A molecular revolution in uveal melanoma: implications for patient care and targeted therapy

JW Harbour, DL Chao - Ophthalmology, 2014 - Elsevier
Uveal melanoma is the most common primary intraocular malignancy and has a strong
propensity for fatal metastasis. Recent advances in the molecular genetics of uveal …

[HTML][HTML] Emerging therapeutic opportunities based on current knowledge of uveal melanoma biology

R Vivet-Noguer, M Tarin, S Roman-Roman, S Alsafadi - Cancers, 2019 - mdpi.com
Uveal Melanoma (UM) is a rare and malignant intraocular tumor with dismal prognosis.
Despite the efficient control of the primary tumor by radiation or surgery, up to 50% of …

Metastatic uveal melanoma: biology and emerging treatments

SE Woodman - The Cancer Journal, 2012 - journals.lww.com
Uveal melanoma is the most common primary intraocular cancer in adults. Nearly half of
primary uveal melanoma tumors metastasize, but there are currently no effective therapies …

Tumor characteristics, genetics, management, and the risk of metastasis in uveal melanoma

EE Nichols, A Richmond, AB Daniels - Seminars in ophthalmology, 2016 - Taylor & Francis
Uveal melanoma is the most common intraocular malignancy in adults. Although rates of
local control for uveal melanoma exceed 95% with radiotherapy or enucleation, as many as …

Uveal melanoma: Progress in molecular biology and therapeutics

Y Li, J Shi, J Yang, S Ge, J Zhang… - … advances in medical …, 2020 - journals.sagepub.com
Uveal melanoma (UM) is the most common intraocular malignancy in adults. So far, no
systemic therapy or standard treatment exists to reduce the risk of metastasis and improve …

Recent advances in uveal melanoma treatment

B Álvarez‐Rodríguez, A Latorre… - Medicinal Research …, 2017 - Wiley Online Library
Uveal melanoma (UM) is the most common primary intraocular malignancy in adults. Recent
advances in the understanding of molecular characteristics helped to determine which …

[HTML][HTML] Genetic and clinico-pathologic analysis of metastatic uveal melanoma

KG Griewank, J Van De Nes, B Schilling, I Moll… - Modern Pathology, 2014 - Elsevier
Uveal melanoma is the most common malignant tumor of the adult eye. Fifty percent of
tumors will eventually metastasize, and there are no effective treatments for them. Recent …

Uveal melanoma: Towards a molecular understanding

KN Smit, MJ Jager, A de Klein, E Kiliҫ - Progress in retinal and eye …, 2020 - Elsevier
Uveal melanoma is an aggressive malignancy that originates from melanocytes in the eye.
Even if the primary tumor has been successfully treated with radiation or surgery, up to half …

The genetics of uveal melanoma: an emerging framework for targeted therapy

JW Harbour - Pigment cell & melanoma research, 2012 - Wiley Online Library
Uveal melanoma is the second most common form of melanoma and the most common
primary intraocular malignancy. Until recently, very little was known about the genetics of …