The detection and processing of painful stimuli in afferent sensory neurons is critically
dependent on a wide range of different types of voltage-and ligand-gated ion channels …

The transmission and processing of pain signals relies critically on the activities of ion
channels that are expressed in afferent pain fibers. This includes voltage-gated channels, as …

Pain is a quite frequent complaint accompanying numerous pathologies. Among these
pathological cases, numerous neuropathies are retrieved with identified etiologies …

Injury to the nerve can produce changes in dorsal horn function and pain. This facilitated
processing may be mediated in part by voltage-sensitive calcium channels. Activation of …

Chronic pain is a severely debilitating condition that reflects a long-term sensitization of
signal transduction in the afferent pain pathway. Among the key players in this pathway are …

It is well recognized that voltage‐gated calcium (Ca2+) channels modulate the function of
peripheral and central pain pathways by influencing fast synaptic transmission and neuronal …

A large series of different ion channels have been identified and investigated as potential
targets for new medicines for the treatment of a variety of human diseases, including pain …

This review focuses on the importance of voltage-gated calcium channels in modulating and
controlling the function of peripheral and central neurons involved in nociceptive processing …

Pain is an unpleasant sensation experienced when tissues are damaged. Thus, pain
sensation in some way protects body from imminent threat or injury. Peripheral sensory …

Severe chronic pain afflicts a large number of people worldwide but satisfactory relief from
such pain is difficult to achieve with drugs that are currently available, and so there is a great …