Myeloid neoplasms, including acute myeloid leukemia (AML), myeloproliferative neoplasms
(MPNs), and myelodysplastic syndromes (MDS), feature clonal dominance and remodeling …

Recent evidence suggests that the pathogenesis of MPN is primarily driven by the
hematopoietic stem and progenitor cells, together with their mutated progeny, which in turn …

The identification of JAK2/MPL mutations in patients with myeloproliferative neoplasms
(MPN) has led to the clinical development of JAK kinase inhibitors, including ruxolitinib …

Abstract Purpose of Review Chronic inflammation is a characteristic feature of
myeloproliferative neoplasm (MPN) and impacts many aspects of the disease including …

What is the role of inflammation in Myeloproliferative Neoplasms? This is currently a topic of
much debate. In this review, we will discuss experimental results and basic concepts of …

In recent years the evidence is increasing that chronic inflammation may be an important
driving force for clonal evolution and disease progression in the Philadelphia‐negative …

Myeloproliferative neoplasms (MPNs) are clonal hematopoietic stem cell disorders
characterized by activated Janus kinase (JAK)–signal transducer and activator of …

Genetic and functional studies underscore the central role of JAK/STAT signaling in
myeloproliferative neoplasms (MPNs). However, the mechanisms that mediate …

Myeloproliferative neoplasms (MPN) include three main entities: Polycythemia Vera (PV),
Essential Thrombocythemia (ET), and Myelofibrosis (MF). MPN represent a unique model of …

Myeloproliferative neoplasms (MPNs) are a heterogeneous group of clonal diseases
characterized by the excessive and chronic production of mature cells from one or several of …