New insights into the molecular biology of childhood leukemias have stimulated numerous
advances in diagnostic methods, strategies for risk assessment and the development of …

Down syndrome is the most common autosomal chromosomal disorder with incidence
ranging from 1 in 700 to 1: 1,000 live births [1]. The protean manifestation are mental …

Opinion statement Leukemia is the most common pediatric cancer and accounts for
approximately one third of childhood malignancies. There are germline genetic alterations …

It has been recognized that chromosomal abnormalities in childhood leukemia, are linked to
both leukemogenesis and segregate patients into prognostic treatment groups. This is best …

S using a combination of agents. While the late 1940s and 1950s were characterized by
single agent chemotherapy de-INCE CHEMOTHERAPY beginnings 50 years ago by Farber …

Cytogenetic and molecular analyses are essential for the classification of childhood
hematologic malignancies. Nearly all children with leukemia should have an adequate …

Purpose We review recent advances in the biologic understanding and treatment of
childhood acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML), identify …

Remarkable progress has been made in the past decade in the treatment and in the
understanding of the biology of childhood lymphoid and myeloid leukemias. With …

Pediatric leukemia is the single most common malignancy affecting children, representing
up to 30% of all pediatric cancers. Dramatic improvements in survival for acute …

Acute lymphoblastic leukemia (ALL) is classified as B‐lineage ALL (B‐ALL) and T‐lineage
ALL (T‐ALL). The incidence of ALL is almost three times higher in white than black children …