Tumor cells may escape from the immune responses because of defective differentiation of
dendritic cells (DC). Recent studies have found an increased number of regulatory T cells …

Background Human hepatocellular carcinoma (HCC) cells express WT1 and/or
carcinoembryonic antigen (CEA) as potential targets for the induction of antitumor immunity …

CD4+ CD25+ regulatory T cells (Tregs) play an essential role in the establishment and
persistence of tumor immune suppression. Tregs can prevent anti-tumor-specific T cells from …

The purpose of this study was to assess the properties of CD4+ CD25 high/low/negative T
cell subsets and analyze their relation with dendritic cells (DCs) in patients with …

Immuosuppression in tumor-bearing hosts may be a major obstacle in eradicating tumors.
This study investigated whether hepatocellular carcinoma suppressed the functions of …

Dysfunction of the host immune system in cancer patients can be due to a number of factors,
including suppression of tumor-associated antigen reactive lymphocytes by CD4+ CD25+ …

The mechanisms that enable liver cancer to escape elimination by the immune system
remain unclear, but their elucidation may provide novel therapeutic interventions. We …

Hepatocellular carcinoma (HCC) has a poor prognosis with limited therapeutic options. We
propose that local immune responses in patients with HCC are held in check by tumor …

CD4+ type 1 T regulatory (Tr1) cells have a crucial role in inducing tolerance. Immune
regulation by these cells is mainly mediated through the secretion of high amounts of IL-10 …

AIM: To analyze the phenotype and function of dendritic cells (DC) from patients with
hepatocellular carcinoma (HCC) in order to understand their role in this disease. METHODS …