Inflammation is an essential component of several respiratory diseases, such as chronic
obstructive pulmonary disease (COPD), asthma and acute respiratory distress syndrome …

Respiratory failure associated with COVID-19 has placed focus on the lungs. Here, we
present single-nucleus accessible chromatin profiles of 90,980 nuclei and matched single …

Methods We evaluated a comprehensive set of transcriptomic data sets to investigate the
associations of smoking with ACE2, FURIN, and TMPRSS2 gene expression in lung tissues …

Lung cancer remains one of the most common malignancies in the world. Nowadays, the
most common lung cancer is non-small cell lung cancer (NSCLC), namely …

Patients with chronic lung disease (CLD) have an increased risk for severe coronavirus
disease-19 (COVID-19) and poor outcomes. Here, we analyze the transcriptomes of …

The lung is the primary organ targeted by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), making respiratory failure a leading coronavirus disease 2019 (COVID-19) …

The COVID-19 pandemic has been a public health issue around the world in the last few
years. Currently, there is no specific antiviral treatment to fight the disease. Thus, it is …

MicroRNAs (miRNAs) are critical modulators of endothelial homeostasis, which highlights
their involvement in vascular diseases, including those caused by virus infections. Our main …

Epigenetics comprise a diverse array of reversible and dynamic modifications to the cell's
genome without implicating any DNA sequence alterations. Both the external environment …

ABSTRACT COVID-19 is often related to hyperinflammation that drives lung or multiorgan
injury. The immunopathological mechanisms that cause excessive inflammation are under …