Discovery of promising cholinesterase inhibitors for Alzheimer's disease treatment through DFT, docking, and molecular dynamics studies of eugenol derivatives
Cholinesterase enzymes are promising drug targets for the symptomatic treatment of
Alzheimer's disease. Indeed, the activity inhibition of these acetylcholine‐degrading …
Alzheimer's disease. Indeed, the activity inhibition of these acetylcholine‐degrading …
Coumarin derivatives as acetyl-and butyrylcholinestrase inhibitors: An in vitro, molecular docking, and molecular dynamics simulations study
MN Abu-Aisheh, A Al-Aboudi, MS Mustafa… - Heliyon, 2019 - cell.com
Alzheimer's disease is an irreversible and progressive brain disease that can cause
problems with memory and thinking skills. It is characterized by loss of cognitive ability and …
problems with memory and thinking skills. It is characterized by loss of cognitive ability and …
Citronellal as a promising candidate for Alzheimer's disease treatment: A comprehensive study on in silico and in vivo anti-acetylcholine esterase activity
DS Prasanth, MKR Shadakshara, SF Ahmad… - Metabolites, 2023 - mdpi.com
One of the primary therapeutic approaches for managing Alzheimer's disease (AD) involves
the modulation of Acetylcholine esterase (AChE) activity to elevate acetylcholine (ACh) …
the modulation of Acetylcholine esterase (AChE) activity to elevate acetylcholine (ACh) …
Acetylcholinesterase inhibition of Alzheimer's disease: Identification of potential phytochemicals and designing more effective derivatives to manage disease condition
Alzheimer's disease (AD) is a brain disease characterized by gradual memory loss and
cognitive impairments. Acetylcholinesterase (AChE) inhibitors—such as donepezil …
cognitive impairments. Acetylcholinesterase (AChE) inhibitors—such as donepezil …
Synthesis, biological evaluation and molecular modeling studies of modulated benzyloxychalcones as potential acetylcholinesterase inhibitors
Acetylcholinesterase inhibitors (AChEIs) have become a significant target in the search for
an efficient treatment of Alzheimer's disease. Chalcone-based compounds display a strong …
an efficient treatment of Alzheimer's disease. Chalcone-based compounds display a strong …
Discovery of a new donepezil-like acetylcholinesterase inhibitor for targeting Alzheimer's disease: computational studies with biological validation
BA Akhoon, S Choudhary, H Tiwari… - Journal of Chemical …, 2020 - ACS Publications
Alzheimer's disorder is one of the most common worldwide health problems, and its
prevalence continues to increase, thereby straining the healthcare budgets of both …
prevalence continues to increase, thereby straining the healthcare budgets of both …
[HTML][HTML] Novel ligand-based docking; molecular dynamic simulations; and absorption, distribution, metabolism, and excretion approach to analyzing potential …
Acetylcholinesterase (AChE) plays an important role in Alzheimer's disease (AD). The
excessive activity of AChE causes various neuronal problems, particularly dementia and …
excessive activity of AChE causes various neuronal problems, particularly dementia and …
Identification of novel acetylcholinesterase inhibitors through e-pharmacophore-based virtual screening and molecular dynamics simulations
Alzheimer's disease (AD), a progressive neurodegenerative disorder is the most common
cause of dementia among elderly people. To date, the successful therapeutic strategy to …
cause of dementia among elderly people. To date, the successful therapeutic strategy to …
Design and development of novel p-aminobenzoic acid derivatives as potential cholinesterase inhibitors for the treatment of Alzheimer's disease
Based on the quantitative structure-activity relationship (QSAR), some novel p-
aminobenzoic acid derivatives as promising cholinesterase enzyme inhibitors were …
aminobenzoic acid derivatives as promising cholinesterase enzyme inhibitors were …
Molecular modeling studies of piperidine derivatives as new acetylcholinesterase inhibitors against neurodegenerative diseases
EFF da Cunha, JE Resende, TCC Franca… - Journal of …, 2013 - Wiley Online Library
Neurodegenerative disorders are related to the progressive loss of structure or function and,
eventually, death of neurons. These processes are responsible for diseases like …
eventually, death of neurons. These processes are responsible for diseases like …
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