Interest for cancer vaccination started more than 30 years ago after the demonstration that
both in animal models and later on in patients it is possible to generate anti-tumor immune …

In recent years, relying on the human immune system to kill tumour cells has become an
effective means of cancer treatment. The development of peptide vaccines, which not only …

Highlights•The recent findings in basic immunology revisit the use of peptide vaccine for
cancer.•Peptide size, formulation and delivery route are critical for peptide vaccine …

The success of the immune checkpoint blockade has provided a proof of concept that
immune cells are capable of attacking tumors in the clinic. However, clinical benefit is only …

Current developments with peptide-based human tumor vaccines : Current Opinion in
Oncology Current developments with peptide-based human tumor vaccines : Current Opinion …

Peptides are the smallest antigenic components that are recognized by T cells when
presented in MHC molecules on the cell surface. After the identification of peptides from …

The use of peptide‑based vaccines as therapeutics aims to elicit immune responses through
antigenic epitopes derived from tumor antigens. Peptide‑based vaccines are easily …

Highlights•Cancer vaccines have not generated effective anti-tumor responses due to
suboptimal immunogenicity.•Peptide vaccines with appropriate adjuvants are the most …

Due to the enormous benefits derived from host immune response, immunotherapy has
been regarded among the most effective methods for defending against cancers …

Throughout the past 3 decades, along with the recognition that the immune system not only
influences oncogenesis and tumor progression, but also determines how established …