In previous years, three‑dimensional (3D) cell culture technology has become a focus of
research in tumor cell biology, using a variety of methods and materials to mimic the in vivo …

High attrition of new oncology drug candidates in clinical trials is partially caused by the poor
predictive capacity of artificial monolayer cell culture assays early in drug discovery …

Abstract Three-dimensional (3D) cell culture systems have gained increasing interest in
drug discovery and tissue engineering due to their evident advantages in providing more …

Cell culture is a widely used in vitro tool for improving our understanding of cell biology,
tissue morphology, and mechanisms of diseases, drug action, protein production and the …

Cells, grown as monolayers (2D models), are routinely used as initial model systems for
evaluating the effectiveness and safety of libraries of molecules with potential as therapeutic …

Cell culture is an indispensable in vitro tool used to improve our perception and
understanding of cell biology, the development of tissue engineering, tissue morphology …

Abstract Three-dimensional (3D) cell culture technology has been steadily studied since the
1990's due to its superior biocompatibility compared to the conventional two-dimensional …

For decades, 2D cell culture format on plastic has been the main workhorse in cancer
research. Though many important understandings of cancer cell biology were derived using …

Tumors develop within complex cell-to-cell interactions, with accessory cells playing a
relevant role starting in the early phases of cancer progression. This event occurs in a three …

Cancer cell lines have contributed immensely in understanding the complex physiology of
cancers. They are excellent material for studies as they offer homogenous samples without …