The temporal control of mitotic protein degradation remains incompletely understood. In
particular, it is unclear why the mitotic checkpoint prevents the anaphase-promoting …

The Anaphase Promoting Complex/Cyclosome (APC/C) in complex with its co‐activator
Cdc20 is responsible for targeting proteins for ubiquitin‐mediated degradation during …

The APC/C is an E3 ubiquitin ligase that, by targeting substrates for proteasomal
degradation, plays a major role in cell cycle control. In complex with one of two WD40 …

Nek2 is a NIMA-related kinase implicated in regulating centrosome structure at the G 2/M
transition. Two splice variants have been identified that exhibit distinct patterns of expression …

DNA damage-induced cell-cycle checkpoints have a critical role in maintaining genomic
stability,. A key target of the checkpoints is the CDC25A (cell division cycle 25 homologue A) …

Progress through mitosis requires that the right protein be degraded at the right time. One
ubiquitin ligase, the anaphase-promoting complex or cyclosome (APC/C) targets most of the …

Mitotic progression is driven by proteolytic destruction of securin and cyclins. These proteins
are labeled for destruction by an ubiquitin-protein isopeptide ligase (E3) known as the …

The ubiquitin protein ligase anaphase-promoting complex or cyclosome (APC/C) controls
mitosis by promoting ordered degradation of securin, cyclins, and other proteins. The …

Progression through mitosis and cytokinesis requires the sequential proteolysis of several
cell-cycle regulators. This proteolysis is mediated by the ubiquitin-proteasome system, with …

In mitosis, the duplicated chromosomes are separated and equally distributed to progeny
cells under the guidance of the spindle, a dynamic microtubule network. Previous studies …