Purpose Collagen and fibrin are known to have potential use as a local drug-delivery
system. This experimental study was designed to evaluate whether a fibrinogen-based …

Background: Local antimicrobial systems have gained importance, as illustrated by current,
research on drug delivery systems (DDS). We aimed to develop materials that combine …

Objective To assess the effect of rifampicin on the haemostatic function of a fibrinogen-
impregnated collagen fleece. Design Laboratory experiment. Setting Government research …

Fibrin glue (FG) has been successfully used in a wide range of surgical fields such as skin
graft fixation, nerve repair, cartilage reattachment and microvascular anastomoses. The …

Fibrin is a natural biopolymer involved in the coagulation cascade. It acts as a reservoir for
growth factors, cells, and enzymes during wound healing and provides a scaffold for the …

The administration of antibiotics is thought of as a commonplace matter. These drugs are
usually given systemically in the hospital setting, and either systemically or topically under …

This chapter summarizes the research experience using a commercial pooled fibrin sealant
(FS) as the delivery vehicle, both in vitro and in vivo, for several drugs and biologies. The …

The addition of antibiotics to an adhesive haemostat results in an ideal system for the
treatment of a localized infectious disease. Fibrin sealant (FS) is a biocompatible …

Background Many chronic wounds have inadequate blood supply around the wounds and
systemic antibiotics are less efficient. Topical antiseptic can cause cytotoxicity and irritation …

Collagen implants of various structures and a gelatine sponge were placed in five different
antibiotic solutions until complete saturation occurred. The antibiotics were chosen to …