Cardiovascular diseases (CVDs) are the leading causes of mortality worldwide. As a type of
CVDs, myocardial infarction (MI) induces ischemia hypoxia, which leads to excessive …

Background: Ferroptosis has been found to play an important role in myocardial ischemia
reperfusion (MIR) injury (MIRI). This study aimed to explore whether the improvement effect …

Background: Myocardial ischemia-reperfusion (I/R) injury causes cardiac dysfunction to
myocardial cell loss and fibrosis. Prevention of cell death is important to protect cardiac …

Abstract The SLC7A11/GPX4 axis plays an important role in ferroptosis during cardiac
ischemia/reperfusion injury (IRI). The present study was designed to evaluate the impact of …

The present study aimed to investigate whether dexmedetomidine (Dex) exerts
cardioprotection effect through inhibiting ferroptosis. Myocardial ischemia/reperfusion injury …

Purpose Myocardial ischemic reperfusion injury (MIRI) is a crucial clinical problem globally.
The molecular mechanisms of MIRI need to be fully explored to develop new therapeutic …

Reports indicate that the mechanism of doxorubicin (Dox)-induced cardiotoxicity is very
complex, involving multiple regulatory cell death forms. Furthermore, the clinical intervention …

Background Epigallocatechin gallate (EGCG) has multiple biological effects such as anti-
tumor multiple drug resistance, antioxidation and anti-inflammatory properties. Ferroptosis is …

Resveratrol (Res) is a polyphenol with a variety of biological activities. However, whether
Res can prevent myocardial ischemia–reperfusion (I/R) injury is not yet known. This study …

Myocardial infarction (MI) is caused by the formation of plaques in the arterial walls, leading
to a decrease of blood flow to the heart and myocardium injury as a result of hypoxia …