We can now predict the development of type 1 diabetes in man because it is a chronic
autoimmune disorder with defined stages of disease. We can also readily prevent the …

The past quarter century has seen a rapid increase in our knowledge about the natural
history of autoimmune type 1 diabetes. However, we stand unable to achieve our ultimate …

Thirty years ago, a convergence of investigational observations lead to the now widely
accepted notion that type 1 diabetes results from an autoimmune destruction of insulin …

Type 1 diabetes can be diagnosed at any age, but dinical course, genetic, and
environmental determinants appear to be heterogenous by age. The common pathway …

A wealth of data in animal models indicates that type 1A diabetes results from T cell‐
mediated specific destruction of islet β cells. There is evidence for the NOD mouse model …

Research into the molecular etiology of type I diabetes mellitus is ongoing in several
promising areas. The goals of investigation include the identification of the genes …

Improved understanding of the pathogenesis of type 1 diabetes mellitus has completely
changed our view of this disease in the past 25 years—from an acute, fulminant disease, to …

Type 1 diabetes | Nature Immunology Skip to main content Thank you for visiting nature.com.
You are using a browser version with limited support for CSS. To obtain the best experience …

We can now predict the development of Type 1A (Immune Mediated) diabetes primarily
through the determination of four biochemically characterized islet autoantibodies [insulin …

The purpose of this article is to provide an overview that summarizes much in the way of our
current state of knowledge regarding the pathogenesis and natural history of type 1 diabetes …