METTL3-mediated m6A modification is required for cerebellar development
N 6-methyladenosine (m6A) RNA methylation is the most abundant modification on mRNAs
and plays important roles in various biological processes. The formation of m6A is catalyzed …
and plays important roles in various biological processes. The formation of m6A is catalyzed …
m6A Regulates Neurogenesis and Neuronal Development by Modulating Histone Methyltransferase Ezh2
J Chen, YC Zhang, C Huang, H Shen… - Genomics …, 2019 - academic.oup.com
Abstract N 6-methyladenosine (m 6 A), catalyzed by the methyltransferase complex
consisting of Mettl3 and Mettl14, is the most abundant RNA modification in mRNAs and …
consisting of Mettl3 and Mettl14, is the most abundant RNA modification in mRNAs and …
The m6A epitranscriptome on neural development and degeneration
YP Yen, JA Chen - Journal of biomedical science, 2021 - Springer
Abstract N 6-methyladenosine (m 6 A) is the most prevalent, conserved, and abundant RNA
modification of the mRNAs of most eukaryotes, including mammals. Similar to epigenetic …
modification of the mRNAs of most eukaryotes, including mammals. Similar to epigenetic …
Temporal control of mammalian cortical neurogenesis by m6A methylation
Summary N 6-methyladenosine (m 6 A), installed by the Mettl3/Mettl14 methyltransferase
complex, is the most prevalent internal mRNA modification. Whether m 6 A regulates …
complex, is the most prevalent internal mRNA modification. Whether m 6 A regulates …
Emerging roles of N6-methyladenosine modification in neurodevelopment and neurodegeneration
L Shu, X Huang, X Cheng, X Li - Cells, 2021 - mdpi.com
N6-methyladenosine (m6A), the most abundant modification in messenger RNAs (mRNAs),
is deposited by methyltransferases (“writers”) Mettl3 and Mettl14 and erased by …
is deposited by methyltransferases (“writers”) Mettl3 and Mettl14 and erased by …
The rRNA m6A methyltransferase METTL5 is involved in pluripotency and developmental programs
VV Ignatova, P Stolz, S Kaiser… - Genes & …, 2020 - genesdev.cshlp.org
Covalent chemical modifications of cellular RNAs directly impact all biological processes.
However, our mechanistic understanding of the enzymes catalyzing these modifications …
However, our mechanistic understanding of the enzymes catalyzing these modifications …
RNA m6A methylation participates in regulation of postnatal development of the mouse cerebellum
C Ma, M Chang, H Lv, ZW Zhang, W Zhang, X He… - Genome biology, 2018 - Springer
Abstract Background N 6-methyladenosine (m 6 A) is an important epitranscriptomic mark
with high abundance in the brain. Recently, it has been found to be involved in the …
with high abundance in the brain. Recently, it has been found to be involved in the …
Alternative splicing of METTL3 explains apparently METTL3-independent m6A modifications in mRNA
N 6-methyladenosine (m6A) is a highly prevalent mRNA modification that promotes
degradation of transcripts encoding proteins that have roles in cell development …
degradation of transcripts encoding proteins that have roles in cell development …
Mettl14 is required for mouse post-implantation development by facilitating epiblast maturation
TG Meng, X Lu, L Guo, GM Hou, XS Ma, QN Li… - bioRxiv, 2018 - biorxiv.org
ABSTRACT N6-methyladenosine (m6A) is the most prevalent and reversible internal
modification of mammalian messenger and noncoding RNAs mediated by specific m6A …
modification of mammalian messenger and noncoding RNAs mediated by specific m6A …
The 18S rRNA m6A methyltransferase METTL5 promotes mouse embryonic stem cell differentiation
RNA modifications represent a novel layer of regulation of gene expression. Functional
experiments revealed that N6‐methyladenosine (m6A) on messenger RNA (mRNA) plays …
experiments revealed that N6‐methyladenosine (m6A) on messenger RNA (mRNA) plays …