Amino acid availability is crucial for cancer cells' survivability. Leukemia and colorectal
cancer cells have been shown to resist asparagine depletion by utilizing GSK3-dependent …

The tolerance of amino acid starvation is fundamental to robust cellular fitness. Asparagine
depletion is lethal to some cancer cells, a vulnerability that can be exploited clinically. We …

General control nonderepressible 2 (GCN2) plays a major role in the cellular response to
amino acid limitation. Although maintenance of amino acid homeostasis is critical for tumor …

GSK3α and GSK3β are two GSK3 isoforms with 84% overall identity and 98% identity in
their catalytic domains. GSK3β plays important roles in the pathogenesis of cancer, while …

Serine-arginine protein kinase 1 (SRPK1) phosphorylates proteins involved in the regulation
of several mRNA processing pathways including alternative splicing. SRPK1 has been …

Ribosomal S6 Kinase 2 (RSK2) is a member of the p90RSK family of serine/threonine
kinases, which are widely expressed and respond to many growth factors, peptide …

Glycogen Synthase Kinase-3 alpha (GSK3A) and beta (GSK3B) isoforms are encoded by
distinct genes, are 98% identical within their kinase domain and perform similar functions in …

Nutrient availability is a key determinant of tumor cell behavior. While nutrient‐rich
conditions favor proliferation and tumor growth, scarcity, and particularly glutamine …

Purpose Gastric cancer is one of the most common cancers with high mortality. Emerging
evidences show that ribosomal s6 kinase4 (RSK4) may be an anti-oncogene in several …

The 90 kDa ribosomal S6 kinases (RSKs) are serine threonine kinases comprising four
isoforms. The isoforms can have overlapping functions in regulation of migration, invasion …