Aim: To determine the accuracy of international warfarin pharmacogenetic algorithms
developed on large multiethnic cohorts (comprising more than 1000 subjects) to predict …

Background Warfarin remains a difficult drug to use due to the large variability in dose
response. Clear understanding of the accuracy of warfarin pharmacogenetic dosing …

The aim of this study was to determine how genetic variants contribute to warfarin dosing
variability when non-genetic factors are controlled. Thirty healthy subjects were subjected to …

Abstract Background/Aims: Data from previous reports, addressing the significance of
genotype-guided dosing of warfarin in Egyptian patients, are infrequent and controversial …

Initiation of warfarin therapy using trial‐and‐error dosing is problematic. Our goal was to
develop and validate a pharmacogenetic algorithm. In the derivation cohort of 1,015 …

INTRODUCTION: Multiple warfarin pharmacogenetic algorithms have been confirmed to
predict warfarin dose more accurately than clinical algorithm or the fixed-dose approach …

Background: Warfarin dosing is difficult to establish because of considerable interindividual
variation. Thus, warfarin pharmacogenetics have attracted particular interest in relation to …

Aims: Multiple warfarin pharmacogenetic dosing algorithms have been reported to date.
However, there is only limited information available on the performance of the algorithms …

Background: Gene-based warfarin dosing algorithms have largely been developed in
homogeneous populations, and their generalizability has not been established. Objectives …

Warfarin is a widely prescribed drug that is difficult to use because of its narrow therapeutic
window. Genetic polymorphisms associated with warfarin metabolism have been identified …