Fungal secondary metabolism: regulation, function and drug discovery
NP Keller - Nature Reviews Microbiology, 2019 - nature.com
One of the exciting movements in microbial sciences has been a refocusing and
revitalization of efforts to mine the fungal secondary metabolome. The magnitude of …
revitalization of efforts to mine the fungal secondary metabolome. The magnitude of …
Unlocking fungal cryptic natural products
YM Chiang, KH Lee, JF Sanchez… - Natural product …, 2009 - journals.sagepub.com
Recent published sequencing of fungal genomes has revealed that these microorganisms
have a surprisingly large number of secondary metabolite pathways that can serve as …
have a surprisingly large number of secondary metabolite pathways that can serve as …
Biosynthetic gene clusters and the evolution of fungal chemodiversity
Covering: up to 2019 Fungi produce a remarkable diversity of secondary metabolites: small,
bioactive molecules not required for growth but which are essential to their ecological …
bioactive molecules not required for growth but which are essential to their ecological …
From genomics to metabolomics, moving toward an integrated strategy for the discovery of fungal secondary metabolites
T Hautbergue, EL Jamin, L Debrauwer, O Puel… - Natural Product …, 2018 - pubs.rsc.org
Fungal secondary metabolites are defined by bioactive properties that ensure adaptation of
the fungus to its environment. Although some of these natural products are promising …
the fungus to its environment. Although some of these natural products are promising …
Biologically active secondary metabolites from the fungi
Many Fungi have a well-developed secondary metabolism. The diversity of fungal species
and the diversification of biosynthetic gene clusters underscores a nearly limitless potential …
and the diversification of biosynthetic gene clusters underscores a nearly limitless potential …
[HTML][HTML] Developing fungal heterologous expression platforms to explore and improve the production of natural products from fungal biodiversity
X Meng, Y Fang, M Ding, Y Zhang, K Jia, Z Li… - Biotechnology …, 2022 - Elsevier
Natural products from fungi represent an important source of biologically active metabolites
notably for therapeutic agent development. Genome sequencing revealed that the number …
notably for therapeutic agent development. Genome sequencing revealed that the number …
Toward awakening cryptic secondary metabolite gene clusters in filamentous fungi
Mining for novel natural compounds is of eminent importance owing to the continuous need
for new pharmaceuticals. Filamentous fungi are historically known to harbor the genetic …
for new pharmaceuticals. Filamentous fungi are historically known to harbor the genetic …
Regulation of fungal secondary metabolism
AA Brakhage - Nature Reviews Microbiology, 2013 - nature.com
Fungi produce a multitude of low-molecular-mass compounds known as secondary
metabolites, which have roles in a range of cellular processes such as transcription …
metabolites, which have roles in a range of cellular processes such as transcription …
Correlative metabologenomics of 110 fungi reveals metabolite–gene cluster pairs
Natural products research increasingly applies-omics technologies to guide molecular
discovery. While the combined analysis of genomic and metabolomic datasets has proved …
discovery. While the combined analysis of genomic and metabolomic datasets has proved …
Harnessing diverse transcriptional regulators for natural product discovery in fungi
Covering: Up to March 2019 Secondary metabolites (SMs) are chemical entities produced
by organisms in response to environmental stimuli and as a defense against biological …
by organisms in response to environmental stimuli and as a defense against biological …