Fungal secondary metabolism: regulation, function and drug discovery

NP Keller - Nature Reviews Microbiology, 2019 - nature.com
One of the exciting movements in microbial sciences has been a refocusing and
revitalization of efforts to mine the fungal secondary metabolome. The magnitude of …

Unlocking fungal cryptic natural products

YM Chiang, KH Lee, JF Sanchez… - Natural product …, 2009 - journals.sagepub.com
Recent published sequencing of fungal genomes has revealed that these microorganisms
have a surprisingly large number of secondary metabolite pathways that can serve as …

Biosynthetic gene clusters and the evolution of fungal chemodiversity

A Rokas, ME Mead, JL Steenwyk, HA Raja… - Natural product …, 2020 - pubs.rsc.org
Covering: up to 2019 Fungi produce a remarkable diversity of secondary metabolites: small,
bioactive molecules not required for growth but which are essential to their ecological …

From genomics to metabolomics, moving toward an integrated strategy for the discovery of fungal secondary metabolites

T Hautbergue, EL Jamin, L Debrauwer, O Puel… - Natural Product …, 2018 - pubs.rsc.org
Fungal secondary metabolites are defined by bioactive properties that ensure adaptation of
the fungus to its environment. Although some of these natural products are promising …

Biologically active secondary metabolites from the fungi

GF Bills, JB Gloer - Microbiology spectrum, 2016 - Am Soc Microbiol
Many Fungi have a well-developed secondary metabolism. The diversity of fungal species
and the diversification of biosynthetic gene clusters underscores a nearly limitless potential …

[HTML][HTML] Developing fungal heterologous expression platforms to explore and improve the production of natural products from fungal biodiversity

X Meng, Y Fang, M Ding, Y Zhang, K Jia, Z Li… - Biotechnology …, 2022 - Elsevier
Natural products from fungi represent an important source of biologically active metabolites
notably for therapeutic agent development. Genome sequencing revealed that the number …

Toward awakening cryptic secondary metabolite gene clusters in filamentous fungi

FY Lim, JF Sanchez, CCC Wang, NP Keller - Methods in enzymology, 2012 - Elsevier
Mining for novel natural compounds is of eminent importance owing to the continuous need
for new pharmaceuticals. Filamentous fungi are historically known to harbor the genetic …

Regulation of fungal secondary metabolism

AA Brakhage - Nature Reviews Microbiology, 2013 - nature.com
Fungi produce a multitude of low-molecular-mass compounds known as secondary
metabolites, which have roles in a range of cellular processes such as transcription …

Correlative metabologenomics of 110 fungi reveals metabolite–gene cluster pairs

LK Caesar, FA Butun, MT Robey, NJ Ayon… - Nature chemical …, 2023 - nature.com
Natural products research increasingly applies-omics technologies to guide molecular
discovery. While the combined analysis of genomic and metabolomic datasets has proved …

Harnessing diverse transcriptional regulators for natural product discovery in fungi

HN Lyu, HW Liu, NP Keller, WB Yin - Natural Product Reports, 2020 - pubs.rsc.org
Covering: Up to March 2019 Secondary metabolites (SMs) are chemical entities produced
by organisms in response to environmental stimuli and as a defense against biological …