Secretion of bicarbonate into the adherent layer of mucus gel creates a pH gradient with a
near-neutral pH at the epithelial surfaces in stomach and duodenum, providing the first line …

The gastric epithelium is covered by a continuous layer of secreted mucus and bicarbonate.
The function of this mucobicarbonate layer in terms of protecting the epithelial cells from …

The gastroduodenal epithelium is covered by an adherent mucus layer into which
bicarbonate is secreted by surface epithelial cells. This mucus‐bicarbonate barrier is an …

How the gastric mucosa is able to withstand intraluminal acid, which can attain
concentrations approaching 155 mM H+ under conditions of maximal stimulation, remains …

We examined the ability of the mucus layer adherent to isolated pieces of rabbit gastric
mucosa to maintain a pH gradient across it. Using antimony microelectrodes, a stable pH …

The barrier that protects the undamaged gastroduodenal mucosa from autodigestion by
gastric juice is a dynamic multicomponent system. The major elements of this barrier are the …

It has long been recognized that gastric mucosa is capable of resisting acid peptic digestion,
but the mechanisms responsible for this have not been adequately explained. An increased …

The factors responsible for prevention of duodenal mucosal injury are not known. This series
of experiments was performed to determine whether the human duodenum secretes …

Mucus thickness is suggested to be related to mucosal protection. We therefore investigated
the importance of the removable mucous layer and epithelial bicarbonate transport in …

Even though there is no general agreement as to the mechanism of gastric mucosal
protection, the consensus is that the initial brunt of luminal insults falls on the mucus layer …