Mesoporous silica nanoparticles for efficient rivastigmine hydrogen tartrate delivery into SY5Y cells

M Karimzadeh, L Rashidi, F Ganji - Drug development and …, 2017 - Taylor & Francis
Rivastigmine hydrogen tartrate (RT) is a molecule with both hydrophilic and hydrophobic
properties used for the treatment of the Alzheimer's disease. In this work, the larger pore size …

Polysorbate-coated mesoporous silica nanoparticles as an efficient carrier for improved rivastigmine brain delivery

SF Basharzad, M Hamidi, A Maleki, Z Karami… - Brain Research, 2022 - Elsevier
Targeted delivery of neurological therapeutic to the brain has been attracting more and more
attention to the treatment of central nervous system (CNS) diseases. Nonetheless, the main …

MCM-41 nanoparticles for brain delivery: better choline-esterase and amyloid formation inhibition with improved kinetics

PK Pandey, AK Sharma, S Rani, G Mishra… - ACS Biomaterials …, 2018 - ACS Publications
The present study was aimed at delivering a low bioavailability drug, rivastigmine hydrogen
tartrate (RTG), to the brain through its encapsulation in mesoporous silica nanoparticles …

Development and evaluation of rivastigmine loaded chitosan nanoparticles for brain targeting

M Fazil, S Md, S Haque, M Kumar, S Baboota… - European Journal of …, 2012 - Elsevier
The rivastigmine (RHT) loaded chitosan nanoparticles (CS-RHT NPs) were prepared by
ionic gelation method to improve the bioavailability and enhance the uptake of RHT to the …

Surface functionalized mesoporous silica nanoparticles as an effective carrier for epirubicin delivery to cancer cells

MY Hanafi-Bojd, MR Jaafari, N Ramezanian… - European Journal of …, 2015 - Elsevier
Recent studies with inorganic nanoparticles modified with functional groups have
demonstrated improvement in drug delivery into cancer cells. In the present study, we …

Evaluation of biomimetically synthesized mesoporous silica nanoparticles as drug carriers: structure, wettability, degradation, biocompatibility and brain distribution

H Li, X Wu, B Yang, J Li, L Xu, H Liu, S Li, J Xu… - Materials Science and …, 2019 - Elsevier
Herein, three kinds of mesoporous silica nanoparticles (BMSs) were biomimetically
synthesized by using heterocyclic amino acid derivatives as template and their the basic …

Development of MCM-41 mesoporous silica nanoparticles as a platform for pramipexole delivery

B Tzankov, V Tzankova, D Aluani, Y Yordanov… - Journal of Drug Delivery …, 2019 - Elsevier
Herein, we present development of new pH-responsive drug delivery systems for D3-
dopamine receptor agonist pramipexole, based on its encapsulation in MCM-41 …

Potential therapeutic effect of nanobased formulation of rivastigmine on rat model of Alzheimer's disease

MF Ismail, AN ElMeshad… - International journal of …, 2013 - Taylor & Francis
Background To sustain the effect of rivastigmine, a hydrophilic cholinesterase inhibitor,
nanobased formulations were prepared. The efficacy of the prepared rivastigmine liposomes …

Functionalized silica nanoparticles as a carrier for Betamethasone Sodium Phosphate: Drug release study and statistical optimization of drug loading by response …

M Ghasemnejad, E Ahmadi, Z Mohamadnia… - Materials Science and …, 2015 - Elsevier
Mesoporous silica nanoparticles with a hexagonal structure (SBA-15) were synthesized and
modified with (3-aminopropyl) triethoxysilane (APTES), and their performance as a carrier …

Development and in vitro safety evaluation of pramipexole-loaded hollow mesoporous silica (HMS) particles

B Tzankov, C Voycheva, Y Yordanov… - Biotechnology & …, 2019 - Taylor & Francis
In this study, spherical hollow mesoporous silica (HMS) particles with average size of 550
nm were loaded with dopamine-receptor agonist pramipexole, as a model drug. High drug …