The role of m6A, m5C and Ψ RNA modifications in cancer: Novel therapeutic opportunities
RNA modifications have recently emerged as critical posttranscriptional regulators of gene
expression programmes. Significant advances have been made in understanding the …
expression programmes. Significant advances have been made in understanding the …
Role of main RNA modifications in cancer: N6-methyladenosine, 5-methylcytosine, and pseudouridine
C Xue, Q Chu, Q Zheng, S Jiang, Z Bao, Y Su… - Signal transduction and …, 2022 - nature.com
Cancer is one of the major diseases threatening human life and health worldwide.
Epigenetic modification refers to heritable changes in the genetic material without any …
Epigenetic modification refers to heritable changes in the genetic material without any …
The roles and implications of RNA m6A modification in cancer
Abstract N 6-Methyladenosine (m6A), the most prevalent internal modification in eukaryotic
mRNA, has been extensively and increasingly studied over the past decade. Dysregulation …
mRNA, has been extensively and increasingly studied over the past decade. Dysregulation …
m6A modification in coding and non-coding RNAs: roles and therapeutic implications in cancer
N 6-Methyladenosine (m 6 A) RNA modification has emerged in recent years as a new layer
of regulatory mechanism controlling gene expression in eukaryotes. As a reversible …
of regulatory mechanism controlling gene expression in eukaryotes. As a reversible …
Novel insight into the regulatory roles of diverse RNA modifications: Re-defining the bridge between transcription and translation
H Shi, P Chai, R Jia, X Fan - Molecular cancer, 2020 - Springer
RNA modifications can be added or removed by a variety of enzymes that catalyse the
necessary reactions, and these modifications play roles in essential molecular mechanisms …
necessary reactions, and these modifications play roles in essential molecular mechanisms …
Crosstalk between RNA m6A modification and non-coding RNA contributes to cancer growth and progression
F Dai, Y Wu, Y Lu, C An, X Zheng, L Dai, Y Guo… - … Therapy-Nucleic Acids, 2020 - cell.com
N6-methyladenosine (m 6 A) is the most common RNA modification and has an important
role in normal development and tumorigenesis. The abnormal expression of m 6 A …
role in normal development and tumorigenesis. The abnormal expression of m 6 A …
Biological roles of RNA m5C modification and its implications in Cancer immunotherapy
H Song, J Zhang, B Liu, J Xu, B Cai, H Yang… - Biomarker …, 2022 - Springer
Epigenetics including DNA and RNA modifications have always been the hotspot field of life
sciences in the post-genome era. Since the first mapping of N6-methyladenosine (m6A) and …
sciences in the post-genome era. Since the first mapping of N6-methyladenosine (m6A) and …
The m6A RNA methylation regulates oncogenic signaling pathways driving cell malignant transformation and carcinogenesis
The m 6 A RNA methylation is the most prevalent internal modification in mammalian
mRNAs which plays critical biological roles by regulating vital cellular processes …
mRNAs which plays critical biological roles by regulating vital cellular processes …
Interplay Between N6-Methyladenosine (m6A) and Non-coding RNAs in Cell Development and Cancer
F Fazi, A Fatica - Frontiers in cell and developmental biology, 2019 - frontiersin.org
RNA chemical modifications in coding and non-coding RNAs have been known for decades.
They are generally installed by specific enzymes and, in some cases, can be read and …
They are generally installed by specific enzymes and, in some cases, can be read and …
The role of m6A RNA methylation in human cancer
XY Chen, J Zhang, JS Zhu - Molecular cancer, 2019 - Springer
Abstract N 6-methyladenosine (m 6 A) is identified as the most common, abundant and
conserved internal transcriptional modification, especially within eukaryotic messenger …
conserved internal transcriptional modification, especially within eukaryotic messenger …