The fungus Cryptococcus neoformans is a major human pathogen with a remarkable
intracellular survival strategy that includes exiting macrophages through non-lytic exocytosis …

ABSTRACT A unique aspect of the interaction of the fungus Cryptococcus neoformans with
macrophages is the phenomenon of nonlytic exocytosis, also referred to as “vomocytosis” or …

For pathogenic microbes to survive ingestion by macrophages, they must subvert powerful
microbicidal mechanisms within the phagolysosome. After ingestion, Candida albicans …

Phagocytosis by cells of the innate immune system, such as macrophages, and the
subsequent successful maturation of the phagosome, is key for the clearance of pathogens …

Cryptococcus neoformans (Cn) is a basidiomycetous pathogenic yeast that is a frequent
cause of meningoencephalitis in immunocompromised individuals. Cn is a facultative …

Cryptococcus neoformans is an environmental yeast that can cause opportunistic infections
in humans. As infecting animals does not form part of its normal life-cycle, it has been …

Understanding of how intracellular pathogens survive in their host cells is important to
improve management of their diseases. This has been fruitful for intracellular bacteria, but it …

Macrophages play a key role in disseminated cryptococcosis, a deadly fungal disease
caused by Cryptococcus neoformans. This opportunistic infection can arise following the …

Upon ingestion by macrophages, Cryptococcus neoformans can survive and replicate
intracellularly unless the macrophages become classically activated. The mechanism …

The lysis of infected cells by disease-causing microorganisms is an efficient but risky
strategy for disseminated infection, as it exposes the pathogen to the full repertoire of the …