As non-canonical nucleic acid secondary structures consisting of cytosine-rich nucleic acids,
i-motifs can form under certain conditions. Several i-motif sequences have been identified in …

Under certain conditions, specific DNA sequences have the potential to adopt noncanonical
secondary structures, such as i‐motifs. Interestingly, these DNA stretches are not randomly …

DNA is naturally dynamic and can self-assemble into alternative secondary structures
including the intercalated motif (i-motif), a four-stranded structure formed in cytosine-rich …

Abstract i-Motifs (iMs) are four-stranded DNA structures that form at cytosine (C)-rich
sequences in acidic conditions in vitro. Their formation in cells is still under debate. We …

Ligands that recognise specific i-motif DNAs are helpful in cancer diagnostics and
therapeutics, as i-motif formation can cause cancer. Although the loop regions of i-motifs are …

Stretches of cytosine-rich DNA are capable of adopting a dynamic secondary structure, the i-
motif. When within promoter regions, the i-motif has the potential to act as a molecular switch …

Stabilizing i-motif structures at neutral pH and physiological temperature remains a major
challenge. Here, we demonstrate the use of chemical end-ligation to stabilize intramolecular …

Abstract i-Motifs (iMs) are non-canonical, four-stranded secondary structures formed by
stacking of hemi-protonated CH+· C base pairs in cytosine-rich DNA sequences …

I-motifs are four-strand noncanonical secondary structures formed by cytosine (C)-rich
sequences in living cells. The structural dynamics of i-motifs play essential roles in many …

During the last decade, the evidence for the biological relevance of i-motif DNA (i-DNA) has
been accumulated. However, relatively few molecules were reported to interact with i-DNA …