Niemann–Pick disease type C (NPC) is caused by mutations in NPC1 or NPC2, which
coordinate egress of low-density-lipoprotein (LDL)-cholesterol from late endosomes. We …

Host–pathogen interactions are important model systems for understanding fundamental
cell biological processes. In this study, we describe a cholesterol-trafficking pathway …

Human adenoviruses (Ads) generally cause mild self-limiting infections but can lead to
serious disease and even be fatal in high-risk individuals, underscoring the importance of …

Niemann-Pick type C disease is an autosomal recessive disorder that leads to massive
accumulation of cholesterol and glycosphingolipids in late endosomes and lysosomes. To …

In human Niemann-Pick Type C (NPC) disease, endosomal trafficking defects lead to an
accumulation of free cholesterol and other lipids in late endosome/lysosome (LE/LY) …

Niemann-Pick C (NPC) disease is a rare recessive lipidosis marked by excessive
accumulation of LDL-derived free cholesterol and glycosphingolipids in the late endosomal …

Niemann‐Pick type C (NPC) disease is a fatal neurodegenerative disorder characterized by
over‐accumulation of low‐density lipoprotein‐derived cholesterol and glycosphingolipids in …

Niemann-Pick disease type C (NPC) is characterized by lysosomal storage of cholesterol
and gangliosides, which results from defects in intracellular lipid trafficking. Most studies of …

Cholesterol is an important precursor for numerous biologically active molecules, and it
plays a major role in membrane structure and function. Cholesterol can be endogenously …

Niemann-Pick disease type C2 is a lipid storage disorder in which mutations in the NPC2
protein cause accumulation of lipoprotein-derived cholesterol in late endosomes and …