Neurotrophin signalling: novel insights into mechanisms and pathophysiology

M Mitre, A Mariga, MV Chao - Clinical science, 2017 - portlandpress.com
Neurotrophins, such as brain-derived neurotrophic factor (BDNF), are prominent regulators
of neuronal survival, growth and differentiation during development. While trophic factors are …

Integral characterization of defective BDNF/TrkB signalling in neurological and psychiatric disorders leads the way to new therapies

GS Tejeda, M Díaz-Guerra - International journal of molecular sciences, 2017 - mdpi.com
Enhancement of brain-derived neurotrophic factor (BDNF) signalling has great potential in
therapy for neurological and psychiatric disorders. This neurotrophin not only attenuates cell …

Neurotrophin signalling in health and disease

MV Chao, R Rajagopal, FS Lee - Clinical science, 2006 - portlandpress.com
Neurotrophins are a unique family of polypeptide growth factors that influence the
proliferation, differentiation, survival and death of neuronal and non-neuronal cells. They are …

The role of neurotrophin signaling in age-related cognitive decline and cognitive diseases

T Numakawa, H Odaka - International Journal of Molecular Sciences, 2022 - mdpi.com
Neurotrophins are a family of secreted proteins expressed in the peripheral nervous system
and the central nervous system that support neuronal survival, synaptic plasticity, and …

Neurotrophin signalling in the human nervous system

S Ateaque, S Merkouris, YA Barde - Frontiers in molecular …, 2023 - frontiersin.org
This review focuses on neurotrophins and their tyrosine kinase receptors, with an emphasis
on their relevance to the function and dysfunction in the human nervous system. It also deals …

Neurotrophins and their receptors: roles in plasticity, neurodegeneration and neuroprotection

A Hennigan, RM O'callaghan, AM Kelly - 2007 - portlandpress.com
It is beyond doubt that the neurotrophin family of proteins plays key roles in determining the
fate of the neuron, not only during embryonic development, but also in the adult brain …

Brain-derived neurotrophic factor: Regulation, effects, and potential clinical relevance

EE Benarroch - Neurology, 2015 - AAN Enterprises
Brain-derived neurotrophic factor (BDNF) is the most ubiquitous and intensively studied
member of the family of neurotrophins in the CNS. The transcriptional regulation of BDNF is …

Challenges of BDNF-based therapies: From common to rare diseases

C Miranda-Lourenço, L Ribeiro-Rodrigues… - Pharmacological …, 2020 - Elsevier
Neurotrophins are a well-known family of neurotrophic factors that play an important role
both in the central and peripheral nervous systems, where they modulate neuronal survival …

BDNF and synaptic plasticity, cognitive function, and dysfunction

B Lu, G Nagappan, Y Lu - Neurotrophic factors, 2014 - Springer
Among all neurotrophins, brain-derived neurotrophic factor (BDNF) stands out for its high
level of expression in the brain and its potent effects on synapses. It is now widely accepted …

Actions of brain-derived neurotrophin factor in the neurogenesis and neuronal function, and its involvement in the pathophysiology of brain diseases

T Numakawa, H Odaka, N Adachi - International journal of molecular …, 2018 - mdpi.com
It is well known that brain-derived neurotrophic factor, BDNF, has an important role in a
variety of neuronal aspects, such as differentiation, maturation, and synaptic function in the …