Insulin-like growth factor-1 promotes synaptogenesis signaling, a major dysregulated pathway in malformation of cortical development, in a rat model

M Lee, EJ Kim, MJ Kim, MS Yum, J Yeom, K Kim - Molecular Neurobiology, 2023 - Springer
Malformation of cortical development (MCD) is one of the main causes of intractable
epilepsy in childhood. We explored a treatment based on molecular changes using an infant …

Early developmental changes in a rat model of malformations of cortical development: Abnormal neuronal migration and altered response to NMDA-induced …

M Lee, EJ Kim, MS Yum - Experimental Neurology, 2024 - Elsevier
Malformations of cortical development (MCDs) are caused by abnormal neuronal migration
processes during the fetal period and are a major cause of intractable epilepsy in infancy …

A new rat model of epileptic spasms based on methylazoxymethanol-induced malformations of cortical development

EH Kim, MS Yum, M Lee, EJ Kim, WH Shim… - Frontiers in …, 2017 - frontiersin.org
Malformations of cortical development (MCDs) can cause medically intractable epilepsies
and cognitive disabilities in children. We developed a new model of MCD-associated …

In vivo MRI Successfully Reveals the Malformation of Cortical Development in Infant Rats

M Lee, EJ Kim, DC Woo, WH Shim… - Frontiers in Neuroscience, 2020 - frontiersin.org
Objective: Malformations of cortical development (MCDs) are major causes of intractable
epilepsies. To characterize the early neuroimaging findings of MCDs, we tried to identify the …

Brain developmental diseases and pathogenic mechanisms

YS Jiang, ZH Xu - Yi Chuan= Hereditas, 2019 - europepmc.org
Development of the human brain is a strictly complex and precisely regulated process. Brain
development includes the proliferation and differentiation of neural progenitor cells …

Rats with malformations of cortical development exhibit decreased length of AIS and hypersensitivity to Pilocarpine-induced status epilepticus

Y Wang, D Sun, Z Yue, W Tang, B Xiao, L Feng - Neurochemical research, 2016 - Springer
Malformations of cortical development (MCD) are critical brain development disorders
associated with varied abnormalities in both anatomic structures and neural functioning. It is …

Why malformations of cortical development cause epilepsy

A Represa - Frontiers in neuroscience, 2019 - frontiersin.org
Malformations of cortical development (MCDs), a complex family of rare disorders, result
from alterations of one or combined developmental steps, including progenitors proliferation …

miRNA expression analysis in cortical dysplasia: regulation of mTOR and LIS1 pathway

JY Lee, AK Park, ES Lee, WY Park, SH Park, JW Choi… - Epilepsy research, 2014 - Elsevier
Cortical dysplasia (CD) is a common cause of epilepsy in children and is characterized by
focal regions of malformed cerebral cortex. The pathogenesis and epileptogenesis of CD …

Basic mechanisms of epileptogenesis in pediatric cortical dysplasia

S Abdijadid, GW Mathern, MS Levine… - CNS neuroscience & …, 2015 - Wiley Online Library
Cortical dysplasia (CD) is a neurodevelopmental disorder due to aberrant cell proliferation
and differentiation. Advances in neuroimaging have proven effective in early identification of …

CXCR4 antagonist AMD3100 suppresses the long-term abnormal structural changes of newborn neurons in the intraventricular kainic acid model of epilepsy

C Song, W Xu, X Zhang, S Wang, G Zhu, T Xiao… - Molecular …, 2016 - Springer
Abnormal hippocampal neurogenesis is a prominent feature of temporal lobe epilepsy (TLE)
models, which is thought to contribute to abnormal brain activity. Stromal cell-derived factor …