The pathways of synthesis and maturation of pre‐messenger RNA in the nucleus have a
direct effect on the translational efficiency of mRNA in the cytoplasm. The transcription of …

MicroRNAs (miRNAs) are noncoding RNAs that base pair imperfectly to homologous
regions in target mRNAs and negatively influence the synthesis of the corresponding …

In eukaryotes, nuclear mRNA synthesis is physically separated from its cytoplasmic
translation and degradation. Recent unexpected findings have revealed that, despite this …

Although it is universally accepted that protein synthesis occurs in the cytoplasm, the
possibility that translation can also take place in the nucleus has been hotly debated …

The sequence of entire genomes from higher eukaryotes revealed that an average gene is
very large due to the interruption of the coding sequence with large noncoding introns …

▪ Abstract Regulation of translation initiation is a central control point in animal cells. We
review our current understanding of the mechanisms of regulation, drawing particularly on …

The translation of mammalian ribosomal protein (rp) mRNAs is selectively repressed in
nongrowing cells. This response is mediated through a regulatory element residing in the …

This volume focuses on the major aspects of post-transcriptional mRNA processing in the
nucleus of eukaryotic cells. Each of the described mRNA reactions is required for proper …

Many years ago, it was the prevailing wisdom that neither the control of messenger RNA
(mRNA) translation nor the control of mRNA degradation was important in the overall …

The control of mammalian mRNA turnover and translation has been linked almost
exclusively to specific cis-elements within the 5'-and 3'-untranslated regions (UTRs) of the …