The Orphan Crop Crassocephalum crepidioides Accumulates the Pyrrolizidine Alkaloid Jacobine in Response to Nitrogen Starvation

S Schramm, W Rozhon, AN Adedeji-Badmus… - Frontiers in Plant …, 2021 - frontiersin.org
Crassocephalum crepidioides is an African orphan crop that is used as a leafy vegetable
and medicinal plant. Although it is of high regional importance in Sub-Saharan Africa, the …

Quantification of the Pyrrolizidine Alkaloid Jacobine in Crassocephalum crepidioides by Cation Exchange High‐Performance Liquid Chromatography

W Rozhon, L Kammermeier, S Schramm… - Phytochemical …, 2018 - Wiley Online Library
Abstract Introduction Pyrrolizidine alkaloids (PAs) are secondary plant metabolites with
considerable hepatoxic, tumorigenic and genotoxic potential. For separation, reversed …

Identification of a Second Site of Pyrrolizidine Alkaloid Biosynthesis in Comfrey to Boost Plant Defense in Floral Stage  ,

LH Kruse, T Stegemann, C Sievert, D Ober - Plant Physiology, 2017 - academic.oup.com
Pyrrolizidine alkaloids (PA s) are toxic secondary metabolites that are found in several
distantly related families of the angiosperms. The first specific step in PA biosynthesis is …

The long road of functional recruitment—The evolution of a gene duplicate to pyrrolizidine alkaloid biosynthesis in the morning glories (Convolvulaceae)

AS Prakashrao, T Beuerle, ARG Simões, C Hopf… - Plant …, 2022 - Wiley Online Library
In plants, homospermidine synthase (HSS) is a pathway‐specific enzyme initiating the
biosynthesis of pyrrolizidine alkaloids (PAs), which function as a chemical defense against …

Seeing double: two different homospermidine oxidases are involved in pyrrolizidine alkaloid biosynthesis in different organs of comfrey (Symphytum officinale)

MM Zakaria, LH Kruse, A Engelhardt… - The Plant …, 2024 - Wiley Online Library
Pyrrolizidine alkaloids (PAs) are toxic specialized metabolites produced in several plant
species and frequently contaminate herbal teas or livestock feed. In comfrey (Symphytum …

Low pyrrolizidine alkaloid levels in perennial ryegrass is associated with the absence of a homospermidine synthase gene

GP Gill, CJ Bryant, M Fokin, J Huege, K Fraser… - BMC plant biology, 2018 - Springer
Abstract Background Pyrrolizidine alkaloids (PAs) are a class of secondary metabolites that
function as feeding deterrents in a range of different plant species. In perennial ryegrass …

Distinct cell-specific expression of homospermidine synthase involved in pyrrolizidine alkaloid biosynthesis in three species of the Boraginales

D Niemüller, A Reimann, D Ober - Plant physiology, 2012 - academic.oup.com
Homospermidine synthase (HSS) is the first specific enzyme in pyrrolizidine alkaloid (PA)
biosynthesis, a pathway involved in the plant's chemical defense. HSS has been shown to …

Recruitment of alkaloid-specific homospermidine synthase (HSS) from ubiquitous deoxyhypusine synthase: Does Crotalaria possess a functional HSS that still has …

N Nurhayati, D Ober - Phytochemistry, 2005 - Elsevier
Quinolizidine alkaloids are the most prominent group of alkaloids occurring in legumes,
except for many members of the tribe Crotalarieae that accumulate pyrrolizidine alkaloids …

Pyrrolizidine Alkaloid Biosynthesis in Phalaenopsis Orchids: Developmental Expression of Alkaloid-Specific Homospermidine Synthase in Root Tips and Young …

S Anke, D Gondé, E Kaltenegger, R Hansch… - Plant …, 2008 - academic.oup.com
Pyrrolizidine alkaloids (PAs) are typical compounds of plant secondary metabolism and are
believed to be part of the plant's chemical defense. Within the monocotyledonous plants …

The effects of promoter variations of the N-Methylcanadine 1-Hydroxylase (CYP82Y1) gene on the noscapine production in opium poppy

D Abedini, SR Monfared, A Abbasi - Scientific Reports, 2018 - nature.com
Noscapine is an antitumor alkaloid produced in opium poppy (Papaver somniferum) and
some members of the Papaveraceae family. It has been primarily used for its antitussive …