Natural compounds: potential therapeutics for the inhibition of cartilage matrix degradation in osteoarthritis
Osteoarthritis (OA) is the most common degenerative joint disease characterized by
enzymatic degradation of the cartilage extracellular matrix (ECM) causing joint pain and …
enzymatic degradation of the cartilage extracellular matrix (ECM) causing joint pain and …
Emodin ameliorates cartilage degradation in osteoarthritis by inhibiting NF-κB and Wnt/β-catenin signaling in-vitro and in-vivo
QH Ding, CY Ye, EM Chen, W Zhang… - International …, 2018 - Elsevier
The overproduction of MMPs (matrix metalloproteinases) and members of the ADAMTS (a
disintegrin and metalloproteinase with thrombospondin motifs) protein family plays an …
disintegrin and metalloproteinase with thrombospondin motifs) protein family plays an …
The Anti-ADAMTS-5 Nanobody® M6495 Protects Cartilage Degradation Ex Vivo
AS Siebuhr, D Werkmann, AC Bay-Jensen… - International Journal of …, 2020 - mdpi.com
Osteoarthritis (OA) is associated with cartilage breakdown, brought about by ADAMTS-5
mediated aggrecan degradation followed by MMP-derived aggrecan and type II collagen …
mediated aggrecan degradation followed by MMP-derived aggrecan and type II collagen …
Identifying chondroprotective diet-derived bioactives and investigating their synergism
RK Davidson, J Green, S Gardner, Y Bao, A Cassidy… - Scientific reports, 2018 - nature.com
Osteoarthritis (OA) is a multifactorial disease and nutrition is a modifiable factor that may
contribute to disease onset or progression. A detailed understanding of mechanisms …
contribute to disease onset or progression. A detailed understanding of mechanisms …
Molecular targets of natural products for chondroprotection in destructive joint diseases
T Jayakumar, P Saravana Bhavan… - International journal of …, 2020 - mdpi.com
Osteoarthritis (OA) is the most common type of arthritis that occurs in an aged population. It
affects any joints in the body and degenerates the articular cartilage and the subchondral …
affects any joints in the body and degenerates the articular cartilage and the subchondral …
Triptolide suppresses proinflammatory cytokine-induced matrix metalloproteinase and aggrecanase-1 gene expression in chondrocytes
A Liacini, J Sylvester, M Zafarullah - Biochemical and Biophysical Research …, 2005 - Elsevier
A hallmark of rheumatoid-and osteoarthritis (OA) is proinflammatory cytokine-induced
degeneration of cartilage collagen and aggrecan by matrix metalloproteinases (MMPs) and …
degeneration of cartilage collagen and aggrecan by matrix metalloproteinases (MMPs) and …
Mechanical loading, cartilage degradation, and arthritis
HB Sun - Annals of the New York Academy of Sciences, 2010 - Wiley Online Library
Joint tissues are exquisitely sensitive to their mechanical environment, and mechanical
loading may be the most important external factor regulating the development and long‐term …
loading may be the most important external factor regulating the development and long‐term …
A synthetic triterpenoid selectively inhibits the induction of matrix metalloproteinases 1 and 13 by inflammatory cytokines
KS Mix, JA Mengshol, U Benbow… - … : Official Journal of …, 2001 - Wiley Online Library
Objective To address the effects of a novel synthetic triterpenoid, 2‐cyano‐3, 12‐dioxoolean‐
1, 9‐dien‐28‐oic acid (CDDO), on the induction of matrix metalloproteinases 1 and 13 (MMP …
1, 9‐dien‐28‐oic acid (CDDO), on the induction of matrix metalloproteinases 1 and 13 (MMP …
[HTML][HTML] Inflammation and joint destruction may be linked to the generation of cartilage metabolites of ADAMTS-5 through activation of toll-like receptors
N Sharma, P Drobinski, A Kayed, Z Chen… - Osteoarthritis and …, 2020 - Elsevier
Objective Links between pain and joint degradation are poorly understood. We investigated
the role of activation of Toll-like receptors (TLR) by cartilage metabolites in initiating and …
the role of activation of Toll-like receptors (TLR) by cartilage metabolites in initiating and …
Discovery of highly potent and selective small molecule ADAMTS-5 inhibitors that inhibit human cartilage degradation via encoded library technology (ELT)
H Deng, H O'Keefe, CP Davie, KE Lind… - Journal of medicinal …, 2012 - ACS Publications
The metalloprotease ADAMTS-5 is considered a potential target for the treatment of
osteoarthritis. To identify selective inhibitors of ADAMTS-5, we employed encoded library …
osteoarthritis. To identify selective inhibitors of ADAMTS-5, we employed encoded library …