Oral nanomedicine for modulating immunity, intestinal barrier functions, and gut microbiome

Y Lee, N Kamada, JJ Moon - Advanced drug delivery reviews, 2021 - Elsevier
The gastrointestinal tract (GIT) affects not only local diseases in the GIT but also various
systemic diseases. Factors that can affect the health and disease of both GIT and the human …

Oral nanomedicine biointeractions in the gastrointestinal tract in health and disease

C Chen, A Beloqui, Y Xu - Advanced drug delivery reviews, 2023 - Elsevier
Oral administration is the preferred route of administration based on the convenience for and
compliance of the patient. Oral nanomedicines have been developed to overcome the …

Oral nanomedicine: challenges and opportunities

B Deng, S Liu, Y Wang, B Ali, N Kong, T Xie… - Advanced …, 2024 - Wiley Online Library
Compared to injection administration, oral administration is free of discomfort, wound
infection, and complications and has a higher compliance rate for patients with diverse …

Nanoparticles for oral delivery: targeted therapy for inflammatory bowel disease

D Li, M Yang, H Xu, M Zhu, Y Zhang, C Tian… - Journal of Materials …, 2022 - pubs.rsc.org
As a group of chronic and idiopathic gastrointestinal (GI) disorders, inflammatory bowel
disease (IBD) is characterized by recurrent intestinal mucosal inflammation. Oral …

Oral polyphenol-armored nanomedicine for targeted modulation of gut microbiota–brain interactions in colitis

H He, Q Qin, F Xu, Y Chen, S Rao, C Wang, X Jiang… - Science …, 2023 - science.org
Developing oral nanomedicines that suppress intestinal inflammation while modulating gut
microbiota and brain interactions is essential for effectively treating inflammatory bowel …

Recent advances in oral nano-antibiotics for bacterial infection therapy

ZL Wu, J Zhao, R Xu - International Journal of Nanomedicine, 2020 - Taylor & Francis
Bacterial infections are the main infectious diseases and cause of death worldwide.
Antibiotics are used to treat various infections ranging from minor to life-threatening ones …

Probiotic‐inspired nanomedicine restores intestinal homeostasis in colitis by regulating redox balance, immune responses, and the Gut Microbiome

J Xu, J Xu, T Shi, Y Zhang, F Chen, C Yang… - Advanced …, 2023 - Wiley Online Library
Microbiota‐based therapeutics offer innovative strategies to treat inflammatory bowel
diseases (IBDs). However, the poor clinical outcome so far and the limited flexibility of the …

[HTML][HTML] Tailoring functional nanoparticles for oral vaccine delivery: recent advances and future perspectives

P Cao, ZP Xu, L Li - Composites Part B: Engineering, 2022 - Elsevier
The oral vaccine has attracted much interest due to easy administration, induction of local
and systemic immune responses, and pain relief. Nowadays, functional nanoparticles and …

Nanoprobiotics for remolding the pro-inflammatory microenvironment and microbiome in the treatment of colitis

J Li, M Sun, L Liu, W Yang, A Sun, J Yu, D Liu… - Nano Letters, 2023 - ACS Publications
Despite the great progress of current bacterially based biotherapeutics, their unsatisfying
efficacy and underlying safety problems have limited their clinical application. Herein …

Oral drug delivery with nanoparticles into the gastrointestinal mucosa

J Liu, P Leng, Y Liu - Fundamental & clinical pharmacology, 2021 - Wiley Online Library
The oral route of protein and peptide drugs has been a popular method of drug delivery in
recent years, although it is often a challenge to achieve effective drug release and minimize …