[HTML][HTML] Focus: drug development: Penicillin's discovery and antibiotic resistance: lessons for the future?

M Lobanovska, G Pilla - The Yale journal of biology and medicine, 2017 - ncbi.nlm.nih.gov
Undoubtedly, the discovery of penicillin is one of the greatest milestones in modern
medicine. 2016 marks the 75th anniversary of the first systemic administration of penicillin in …

[HTML][HTML] The discovery of penicillin—new insights after more than 75 years of clinical use

R Gaynes - Emerging infectious diseases, 2017 - ncbi.nlm.nih.gov
After just over 75 years of penicillin's clinical use, the world can see that its impact was
immediate and profound. In 1928, a chance event in Alexander Fleming's London laboratory …

Penicillin: the medicine with the greatest impact on therapeutic outcomes

N Kardos, AL Demain - Applied microbiology and biotechnology, 2011 - Springer
The principal point of this paper is that the discovery of penicillin and the development of the
supporting technologies in microbiology and chemical engineering leading to its commercial …

[图书][B] Penicillin: triumph and tragedy

R Bud - 2007 - books.google.com
Penicillin is the drug of the twentieth century. It was the first of the antibiotics that, for
decades after the Second World War, underpinned a popular belief that infectious disease …

Reviving the Antibiotic Miracle? As the development of antibiotic-resistant bacteria accelerates, research on new antibiotics lags. But a few promising lines of …

J Travis - Science, 1994 - science.org
13ack in the 1940s and 50s, when the first antibiotics such as penicillin began making their
way into clinical use, they were hailed as miracle drugs-and rightly so. By killing the bacteria …

Update on the antibacterial resistance crisis

AC Croft, AV D'Antoni, SL Terzulli - Medical science monitor, 2007 - medscimonit.com
This nation–and in fact the world–is currently facing a crisis in the form of a growing
antibacterial drug resistance. In the 60 or so years since the discovery of penicillin …

[HTML][HTML] The antibiotic resistance crisis, with a focus on the United States

E Martens, AL Demain - The Journal of antibiotics, 2017 - nature.com
Beginning with the discovery of penicillin by Alexander Fleming in the late 1920s, antibiotics
have revolutionized the field of medicine. They have saved millions of lives each year …

Alexander Fleming and the discovery of penicillin

JW Bennett, KT Chung - 2001 - Elsevier
Publisher Summary Penicillin permanently changed infectious disease research and
therapeutic medicine, it transformed patient expectations and the structures of drug …

Update on the antibiotic resistance crisis

GM Rossolini, F Arena, P Pecile, S Pollini - Current opinion in …, 2014 - Elsevier
Highlights•The antibiotic resistance crisis is jeopardizing feasibility of medical practices.•The
antibiotic resistance crisis is more serious with Gram-negative pathogens.•XDR phenotypes …

The future of antibiotics and resistance

B Spellberg, JG Bartlett, DN Gilbert - New England Journal of …, 2013 - Mass Medical Soc
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