This paper formulates a novel multifactorial Cascade Concept for the pathogenesis of
adolescent idiopathic scoliosis (AIS). This Concept stems from the longitudinal findings of …

The autonomic nervous system through its hypothalamic neuroendocrine control of puberty,
skeletal growth and menarche contributes importantly to the pathogenesis of adolescent …

Background Despite considerable advances in the past few decades, there is no generally
accepted “top theory or theories” of the etiology of adolescent idiopathic scoliosis (AIS). This …

Lower body mass index (BMI) and lower circulating leptin levels have been reported in girls
with AIS. In this paper we evaluate skeletal sizes and asymmetries by higher and lower BMI …

Anthropometric data from three groups of adolescent girls-preoperative adolescent
idiopathic scoliosis (AIS), screened for scoliosis and normals were analysed by comparing …

Study Design. This was a case-control study. Objective. This study aimed to investigate the
body composition and its correlation with leptin and soluble leptin receptor (sOB-R) levels in …

Study Design. Review of the literature on the pathogenesis of adolescent idiopathic scoliosis
(AIS). Objective. To discuss the different theories that have appeared on this subject …

Etiology of adolescent idiopathic scoliosis (AIS), a complicated three-dimensional spinal
deformity with early-onset, receives continuous attention but remains unclear. To gain an …

There is no generally accepted scientific theory for the causes of adolescent idiopathic
scoliosis (AIS). In recent years encouraging advances thought to be related to the …

Although considerable progress had been made in the past two decades in understanding
the etiopathogenesis of adolescent idiopathic scoliosis (AIS), it still lacks an agreed theory of …