New antifungal strategies: drug combination and co-delivery

P Zhu, Y Li, T Guo, S Liu, RJ Tancer, C Hu… - Advanced Drug Delivery …, 2023 - Elsevier
The growing occurrence of invasive fungal infections and the mounting rates of drug
resistance constitute a significant menace to human health. Antifungal drug combinations …

Confronting antifungal resistance, tolerance, and persistence: advances in drug target discovery and delivery systems

L Chen, L Zhang, Y Xie, Y Wang, X Tian, W Fang… - Advanced Drug Delivery …, 2023 - Elsevier
Human pathogenic fungi pose a serious threat to human health and safety. Unfortunately,
the limited number of antifungal options is exacerbated by the continuous emergence of …

[HTML][HTML] Fungal drug response and antimicrobial resistance

P Osset-Trénor, A Pascual-Ahuir, M Proft - Journal of Fungi, 2023 - mdpi.com
Antifungal resistance is a growing concern as it poses a significant threat to public health.
Fungal infections are a significant cause of morbidity and mortality, especially in …

Antifungal therapy: Novel drug delivery strategies driven by new targets

S Wu, R Song, T Liu, C Li - Advanced Drug Delivery Reviews, 2023 - Elsevier
In patients with compromised immunity, invasive fungal infections represent a significant
cause of mortality. Given the limited availability and drawbacks of existing first-line antifungal …

Antifungal drug resistance: evolution, mechanisms and impact

NM Revie, KR Iyer, N Robbins, LE Cowen - Current opinion in …, 2018 - Elsevier
Highlights•Our limited arsenal of antifungals is threatened by drug-resistant fungal
pathogens.•Inherent resistance is when all strains of a species show antifungal …

[HTML][HTML] Augmenting azoles with drug synergy to expand the antifungal toolbox

A Kane, DA Carter - Pharmaceuticals, 2022 - mdpi.com
Fungal infections impact the lives of at least 12 million people every year, killing over 1.5
million. Wide-spread use of fungicides and prophylactic antifungal therapy have driven …

[HTML][HTML] Update on antifungal drug resistance

DS Perlin, E Shor, Y Zhao - Current clinical microbiology reports, 2015 - Springer
Invasive fungal infections remain a major source of global morbidity and mortality, especially
among patients with underlying immune suppression. Successful patient management …

Combinatorial strategies for combating invasive fungal infections

M Spitzer, N Robbins, GD Wright - Virulence, 2017 - Taylor & Francis
Invasive fungal infections are an important cause of human mortality and morbidity,
particularly for immunocompromised populations. However, there remains a paucity of …

[HTML][HTML] Development and research progress of anti-drug resistant fungal drugs

X Cui, L Wang, Y Lue, C Yue - Journal of Infection and Public Health, 2022 - Elsevier
With the widespread use of immunosuppressive agents and the increase in patients with
severe infections, the incidence of fungal infections worldwide has increased year by year …

[HTML][HTML] Drug-resistant fungi: an emerging challenge threatening our limited antifungal armamentarium

A Arastehfar, T Gabaldón, R Garcia-Rubio, JD Jenks… - Antibiotics, 2020 - mdpi.com
The high clinical mortality and economic burden posed by invasive fungal infections (IFIs),
along with significant agricultural crop loss caused by various fungal species, has resulted in …