New antifungal strategies: drug combination and co-delivery
P Zhu, Y Li, T Guo, S Liu, RJ Tancer, C Hu… - Advanced Drug Delivery …, 2023 - Elsevier
The growing occurrence of invasive fungal infections and the mounting rates of drug
resistance constitute a significant menace to human health. Antifungal drug combinations …
resistance constitute a significant menace to human health. Antifungal drug combinations …
Confronting antifungal resistance, tolerance, and persistence: advances in drug target discovery and delivery systems
L Chen, L Zhang, Y Xie, Y Wang, X Tian, W Fang… - Advanced Drug Delivery …, 2023 - Elsevier
Human pathogenic fungi pose a serious threat to human health and safety. Unfortunately,
the limited number of antifungal options is exacerbated by the continuous emergence of …
the limited number of antifungal options is exacerbated by the continuous emergence of …
[HTML][HTML] Fungal drug response and antimicrobial resistance
P Osset-Trénor, A Pascual-Ahuir, M Proft - Journal of Fungi, 2023 - mdpi.com
Antifungal resistance is a growing concern as it poses a significant threat to public health.
Fungal infections are a significant cause of morbidity and mortality, especially in …
Fungal infections are a significant cause of morbidity and mortality, especially in …
Antifungal therapy: Novel drug delivery strategies driven by new targets
S Wu, R Song, T Liu, C Li - Advanced Drug Delivery Reviews, 2023 - Elsevier
In patients with compromised immunity, invasive fungal infections represent a significant
cause of mortality. Given the limited availability and drawbacks of existing first-line antifungal …
cause of mortality. Given the limited availability and drawbacks of existing first-line antifungal …
Antifungal drug resistance: evolution, mechanisms and impact
Highlights•Our limited arsenal of antifungals is threatened by drug-resistant fungal
pathogens.•Inherent resistance is when all strains of a species show antifungal …
pathogens.•Inherent resistance is when all strains of a species show antifungal …
[HTML][HTML] Augmenting azoles with drug synergy to expand the antifungal toolbox
Fungal infections impact the lives of at least 12 million people every year, killing over 1.5
million. Wide-spread use of fungicides and prophylactic antifungal therapy have driven …
million. Wide-spread use of fungicides and prophylactic antifungal therapy have driven …
[HTML][HTML] Update on antifungal drug resistance
Invasive fungal infections remain a major source of global morbidity and mortality, especially
among patients with underlying immune suppression. Successful patient management …
among patients with underlying immune suppression. Successful patient management …
Combinatorial strategies for combating invasive fungal infections
Invasive fungal infections are an important cause of human mortality and morbidity,
particularly for immunocompromised populations. However, there remains a paucity of …
particularly for immunocompromised populations. However, there remains a paucity of …
[HTML][HTML] Development and research progress of anti-drug resistant fungal drugs
X Cui, L Wang, Y Lue, C Yue - Journal of Infection and Public Health, 2022 - Elsevier
With the widespread use of immunosuppressive agents and the increase in patients with
severe infections, the incidence of fungal infections worldwide has increased year by year …
severe infections, the incidence of fungal infections worldwide has increased year by year …
[HTML][HTML] Drug-resistant fungi: an emerging challenge threatening our limited antifungal armamentarium
The high clinical mortality and economic burden posed by invasive fungal infections (IFIs),
along with significant agricultural crop loss caused by various fungal species, has resulted in …
along with significant agricultural crop loss caused by various fungal species, has resulted in …