A review on recent advancement on age-related hearing loss: the applications of nanotechnology, drug pharmacology, and biotechnology

J Chester, E Johnston, D Walker, M Jones, CM Ionescu… - Pharmaceutics, 2021 - mdpi.com
Aging is considered a contributing factor to many diseases such as cardiovascular disease,
Alzheimer's disease, and hearing loss. Age-related hearing loss, also termed presbycusis, is …

[HTML][HTML] Nanodelivery of antioxidant Agents: A promising strategy for preventing sensorineural hearing loss

Z Hajmohammadi, Z Bagher… - European Journal of …, 2024 - Elsevier
Sensorineural hearing loss (SNHL), often stemming from reactive oxygen species (ROS)
generation due to various factors such as ototoxic drugs, acoustic trauma, and aging …

Progress on mechanisms of age-related hearing loss

W Yang, X Zhao, R Chai, J Fan - Frontiers in neuroscience, 2023 - frontiersin.org
Age-related hearing loss, or presbycusis, is a common cause of hearing loss in elderly
people worldwide. It typically presents as progressive, irreversible, and usually affects the …

Application of nanomedicine in inner ear diseases

Q Lin, Q Guo, M Zhu, J Zhang, B Chen, T Wu… - … in Bioengineering and …, 2022 - frontiersin.org
The treatment of inner ear disorders always remains a challenge for researchers. The
presence of various physiological barriers, primarily the blood–labyrinth barrier (BLB), limits …

Probucol-bile acid nanoparticles: A Novel Approach and Promising Solution to Prevent Cellular Oxidative Stress in Sensorineural Hearing Loss.

SR Wagle, B Kovacevic, T Foster… - Journal of Drug …, 2024 - Taylor & Francis
The use of anti-oxidants could thus prove an effective medication to prevent or facilitate
recovery from oxidative stress-induced sensorineural hearing loss (SNHL). One promising …

Pharmaceutical characterization of probucol bile acid–lithocholic acid nanoparticles to prevent chronic hearing related and similar cellular oxidative stress pathologies

SR Wagle, CM Ionescu, B Kovacevic, M Jones… - …, 2023 - Taylor & Francis
Background: Sensorineural hearing loss has been associated with oxidative stress.
However, an antioxidant that passes effectively through the ear remains elusive. Method …

Age-related hearing impairment and the triad of acquired hearing loss

CH Yang, T Schrepfer, J Schacht - Frontiers in cellular neuroscience, 2015 - frontiersin.org
Understanding underlying pathological mechanisms is prerequisite for a sensible design of
protective therapies against hearing loss. The triad of age-related, noise-generated, and …

Mechanisms of sensorineural cell damage, death and survival in the cochlea

ACY Wong, AF Ryan - Frontiers in aging neuroscience, 2015 - frontiersin.org
The majority of acquired hearing loss, including presbycusis, is caused by irreversible
damage to the sensorineural tissues of the cochlea. This article reviews the intracellular …

A new approach to treating neurodegenerative otologic disorders

WH Moos, DV Faller, IP Glavas, DN Harpp… - BioResearch open …, 2018 - liebertpub.com
Hearing loss, the most common neurological disorder and the fourth leading cause of years
lived with disability, can have profound effects on quality of life. The impact of this “invisible …

Current trends in treating hearing loss in elderly people: a review of the technology and treatment options–a mini-review

GM Sprinzl, H Riechelmann - Gerontology, 2010 - karger.com
Abstract Background: According to the World Health Organization (WHO), by 2025 there will
be approximately 1.2 billion people in the world over the age of 60, which marks a shift in …