Neither pain, nor depression exist as independent phenomena per se, they are highly
subjective inner states, formed by our brain and built on the bases of our experiences …

Background: Emotional disorders are common comorbid affectations that exacerbate the
severity and persistence of chronic pain. Specifically, depressive symptoms can lead to an …

Chronic pain represents one of the most important public health problems and, in addition to
classical analgesics, antidepressants are an essential part of the therapeutic strategy. This …

Chronic pain, as a stress state, is one of the critical factors for determining depression, and
their coexistence tends to further aggravate the severity of both disorders. Unfortunately …

[Frontiers in Bioscience 14, 5031-5051, June 1, 2009] 5031 Depression and pain Michael J.
Robinson1, Sara E. Edwards1, Smriti Iy Page 1 [Frontiers in Bioscience 14, 5031-5051, June …

Background: Depression and pain are both burdensome ailments that affect a major
proportion of the population. It is evident that depression and pain frequently coexist, with …

Acute pain induces depressed mood, and chronic pain is known to cause depression.
Depression, meanwhile, can also adversely affect pain behaviors ranging from …

The current knowledge of the pharmacological actions of the tricyclic antidepressants
(TCAs) has slowly evolved through their over 40-year history. Chronic pain represents one …

Results from experimental and clinical studies indicate that antidepressants have specific
analgesic properties in chronic pain. The exact site of action of these drugs (spinal or …

Depressive disorders are chronic conditions that produce both emotional and physical
symptoms. Increasing evidence suggests that in some patients with depressive disorders a …