Loss of kidney function in renal ischemia/reperfusion injury is due to programmed cell death,
but the contribution of necroptosis, a newly discovered form of programmed necrosis, has …

Necroptosis, oxidative stress, and inflammation are major contributors to the pathogenesis of
ischemic acute kidney injury. Necrostatin-1 (Nec-1), an inhibitor of the kinase domain of …

Proper regulation of cell death signaling is crucial for the maintenance of homeostasis and
prevention of disease. A caspase-independent regulated form of cell death called …

Programmed cell death (PCD) had been widely used synonymously to caspase-mediated
apoptosis until caspase-independent cell death was described. Identification of necrosis as …

Receptor-interacting protein kinase 3 (RIPK3)-mediated necroptosis is thought to be the
pathophysiologically predominant pathway that leads to regulated necrosis of parenchymal …

Necroptosis is a type of regulated cell death dependent on the activity of receptor-interacting
serine/threonine-protein (RIP) kinases. However, unlike apoptosis, it is caspase …

Cell death is an important biological process that is believed to have a central role in
intestinal ischaemia/reperfusion (I/R) injury. While the apoptosis inhibition is pivotal in …

Background Programmed necrosis/necroptosis is an emerging form of cell death that plays
important roles in mammalian development and the immune system. The pro-necrotic …

Apoptotic cell death eventually results in secondary necrotic cell death, whereas caspase-
independent primary necrotic cell death has been reported and its mechanism involving …

Accumulating evidence indicatesthat programmed necrosis plays a critical role in cell death
during ischemia–reperfusion. Necrostatin-1 (Nec-1), a small molecule capable of inhibiting a …