Deficiency of prebiotic fiber and insufficient signaling through gut metabolite-sensing receptors leads to cardiovascular disease

DM Kaye, WA Shihata, HA Jama, K Tsyganov… - Circulation, 2020 - Am Heart Assoc
Background: High blood pressure (BP) continues to be a major, poorly controlled but
modifiable risk factor for cardiovascular death. Among key Western lifestyle factors, a diet …

Microbial peer pressure: the role of the gut microbiota in hypertension and its complications

RR Muralitharan, HA Jama, L Xie, A Peh, M Snelson… - …, 2020 - Am Heart Assoc
There is increasing evidence of the influence of the gut microbiota on hypertension and its
complications, such as chronic kidney disease, stroke, heart failure, and myocardial …

High-fiber diet and acetate supplementation change the gut microbiota and prevent the development of hypertension and heart failure in hypertensive mice

FZ Marques, E Nelson, PY Chu, D Horlock, A Fiedler… - Circulation, 2017 - Am Heart Assoc
Background: Dietary intake of fruit and vegetables is associated with lower incidence of
hypertension, but the mechanisms involved have not been elucidated. Here, we evaluated …

How dietary fibre, acting via the gut microbiome, lowers blood pressure

C Xu, FZ Marques - Current Hypertension Reports, 2022 - Springer
Abstract Purpose of Review To discuss the interplay behind how a high-fibre diet leads to
lower blood pressure (BP) via the gut microbiome. Recent Findings Compelling evidence …

Role of gut microbiota-generated short-chain fatty acids in metabolic and cardiovascular health

ES Chambers, T Preston, G Frost, DJ Morrison - Current nutrition reports, 2018 - Springer
Abstract Purpose of this Review This review assesses the latest evidence linking short-chain
fatty acids (SCFA) with host metabolic health and cardiovascular disease (CVD) risk and …

Targeting the gut microbiota with inulin-type fructans: preclinical demonstration of a novel approach in the management of endothelial dysfunction

E Catry, LB Bindels, A Tailleux, S Lestavel… - Gut, 2018 - gut.bmj.com
Objective To investigate the beneficial role of prebiotics on endothelial dysfunction, an early
key marker of cardiovascular diseases, in an original mouse model linking steatosis and …

Essential hypertension is associated with changes in gut microbial metabolic pathways: a multisite analysis of ambulatory blood pressure

M Nakai, RV Ribeiro, BR Stevens, P Gill… - …, 2021 - Am Heart Assoc
Recent evidence supports a role for the gut microbiota in hypertension, but whether
ambulatory blood pressure is associated with gut microbiota and their metabolites remains …

Gut microbiota-derived short-chain fatty acids facilitate microbiota: host cross talk and modulate obesity and hypertension

HB Overby, JF Ferguson - Current hypertension reports, 2021 - Springer
Abstract Purpose of Review The purpose of this review is to summarize the evidence
supporting a role of short-chain fatty acids (SCFAs) as messengers facilitating cross talk …

Probiotics and blood pressure: current insights

A Upadrasta, RS Madempudi - Integrated blood pressure control, 2016 - Taylor & Francis
Gut microbiota play a significant role in host metabolic processes, and recent metagenomic
surveys have revealed that they are involved in host immune modulation and influence host …

Microbial short chain fatty acid metabolites lower blood pressure via endothelial G protein-coupled receptor 41

N Natarajan, D Hori, S Flavahan… - Physiological …, 2016 - journals.physiology.org
Short chain fatty acid (SCFA) metabolites are byproducts of gut microbial metabolism that
are known to affect host physiology via host G protein-coupled receptor (GPCRs). We …