B cells mediate multiple sclerosis (MS) pathogenesis by mechanisms unrelated to
immunoglobulin (Ig). We reported that supernatants (Sup) from cultured B cells from blood of …

B cells are important in the pathogenesis of multiple sclerosis (MS) and some of the effects
are not dependent on maturation of B cells into immunoglobulin (Ig) producing plasmablasts …

Despite the current limited understanding of the etiology of multiple sclerosis (MS), genetic
susceptibility and environmental influences are known driving factors. MS is considered a T …

B cells are increasingly coming into play in the pathogenesis of multiple sclerosis (MS).
Here, we screened peripheral blood mononuclear cells (PBMC) from patients with clinically …

There is much evidence to implicate B cells, plasma cells, and their products in the
pathogenesis of MS. Despite unequivocal evidence that the animal model for MS, EAE, is …

Over the past two decades B cells have increasingly moved into the spotlight in multiple
sclerosis (MS) research. This interest was fuelled by growing understanding and acceptance …

Clonally expanded populations of Ig variable gene-mutated B cells are found in the central
nervous system (CNS) of subjects with multiple sclerosis (MS), suggesting the occurrence of …

B cells are implicated in the etiology of multiple sclerosis (MS). Intrathecal IgG synthesis,
cerebrospinal fluid (CSF) oligoclonal bands and lesional IgG deposition suggest a role for …

[Frontiers in Bioscience 12, 2735-2749, January 1, 2007] 2735 Potential Role of Humoral
Immunity in the Pathogenesis of Multipl Page 1 [Frontiers in Bioscience 12, 2735-2749, January …

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central
nervous system (CNS). The mainstream view is that MS is caused by an autoimmune attack …