In recent decades, neuropsychiatric disorders such as major depressive disorder,
schizophrenia, bipolar, etc., have become a global health concern, causing various …

Depression is a common and serious disorder, characterized by symptoms like anhedonia,
lack of energy, sad mood, low appetite, and sleep disturbances. This disease is very …

The metabolism of L-tryptophan (TRP) regulates homeostasis, immunity, and neuronal
function. Altered TRP metabolism has been implicated in the pathophysiology of various …

Tryptophan (Tryp) is an essential amino acid and the precursor of several neuroactive
compounds within the central nervous system (CNS). Tryp metabolism, the common …

Neurological and psychiatric disorders are a category of chronic diseases that are
widespread and pose serious mental and physical health problems for patients. The …

Emerging evidence suggests that neuroinflammation is involved in both depression and
neurodegenerative diseases. The kynurenine pathway, generating metabolites which may …

Tryptophan is an essential amino acid whose metabolites play key roles in diverse
physiological processes. Due to low reserves in the body, especially under various catabolic …

The link between gut microbiome and brain is being slowly acknowledged due to the
speculated role of resident gut microbial community in altering the functions of gut-brain axis …

Many, if not all, chronic medical, neurodegenerative and neuroprogressive illnesses are
characterised by chronic immune activation, oxidative and nitrosative stress (O) and …

In the past, accelerated tryptophan breakdown was considered to be a feature of clinical
conditions, such as infection, inflammation, and malignant disease. More recently, however …