Advances in the preparation and synthesis of heparin and related products
SN Baytas, RJ Linhardt - Drug Discovery Today, 2020 - Elsevier
Highlights•Metabolic engineering of heparosan, heparin and heparan sulfate•Chemical and
chemoenzymatic synthesis of low molecular weight heparins•Development of new heparin …
chemoenzymatic synthesis of low molecular weight heparins•Development of new heparin …
Engineered heparins as new anticoagulant drugs
Heparin is an anionic polysaccharide that is widely used as a clinical anticoagulant. This
glycosaminoglycan is prepared from animal tissues in metric ton quantities. Animal‐sourced …
glycosaminoglycan is prepared from animal tissues in metric ton quantities. Animal‐sourced …
Synthesis of bioengineered heparin chemically and biologically similar to porcine-derived products and convertible to low MW heparin
M Douaisi, EE Paskaleva, L Fu… - Proceedings of the …, 2024 - National Acad Sciences
Heparins have been invaluable therapeutic anticoagulant polysaccharides for over a
century, whether used as unfractionated heparin or as low molecular weight heparin …
century, whether used as unfractionated heparin or as low molecular weight heparin …
Heparin: past, present, and future
EI Oduah, RJ Linhardt, ST Sharfstein - Pharmaceuticals, 2016 - mdpi.com
Heparin, the most widely used anticoagulant drug in the world today, remains an animal-
derived product with the attendant risks of adulteration and contamination. A contamination …
derived product with the attendant risks of adulteration and contamination. A contamination …
From farm to pharma: an overview of industrial heparin manufacturing methods
The purification of heparin from offal is an old industrial process for which commercial
recipes date back to 1922. Although chemical, chemoenzymatic, and biotechnological …
recipes date back to 1922. Although chemical, chemoenzymatic, and biotechnological …
Recent progress and applications in glycosaminoglycan and heparin research
Heparin, the focus of this review, is a crucially important anticoagulant drug produced from
animal sources, which was contaminated last year leading to a number of adverse side …
animal sources, which was contaminated last year leading to a number of adverse side …
Synthesis of bioengineered heparin by recombinant yeast Pichia pastoris
Y Zhang, Y Wang, Z Zhou, P Wang, X Xi, S Hu… - Green …, 2022 - pubs.rsc.org
Heparin, the most widely used anticoagulant drug, is mainly acquired from livestock.
Variable structures and contaminations of other glycosaminoglycans of animal-sourced …
Variable structures and contaminations of other glycosaminoglycans of animal-sourced …
Chemoenzymatic synthesis of the next generation of ultralow MW heparin therapeutics
S Masuko, RJ Linhardt - Future medicinal chemistry, 2012 - Taylor & Francis
Heparin, a sulfated glycosaminoglycan, is a widely used injectable anticoagulant. This
polysaccharide is a natural product extracted from porcine intestinal tissue. A specific …
polysaccharide is a natural product extracted from porcine intestinal tissue. A specific …
Chemoenzymatic synthesis of ultralow and low-molecular weight heparins
T Wang, L Liu, J Voglmeir - Biochimica et Biophysica Acta (BBA)-Proteins …, 2020 - Elsevier
Heparin is a naturally occurring glycosaminoglycan isolated from animal tissues and is
medically used as an anticoagulant drug. Adulteration attempts of isolated heparin with …
medically used as an anticoagulant drug. Adulteration attempts of isolated heparin with …
Engineering of routes to heparin and related polysaccharides
U Bhaskar, E Sterner, AM Hickey, A Onishi… - Applied microbiology …, 2012 - Springer
Anticoagulant heparin has been shown to possess important biological functions that vary
according to its fine structure. Variability within heparin's structure occurs owing to its …
according to its fine structure. Variability within heparin's structure occurs owing to its …