Pseudomonas aeruginosa causes chronic lung infection in cystic fibrosis (CF), resulting in
structural lung damage and progressive pulmonary decline. P. aeruginosa in the CF lung …

Lipid A is the pro-inflammatory component of bacterial lipopolysaccharide, the major surface
component of Gram-negative bacteria. Gram-negative bacteria alter the structure of lipid A in …

The opportunistic pathogen Pseudomonas aeruginosa is one of the most common agents of
respiratory infections and has been associated with high morbidity and mortality rates. The …

The outcome of an infection depends on host recognition of the pathogen, hence leading to
the activation of signaling pathways controlling defense responses. A long-held belief is that …

Pseudomonas aeruginosa (PA) infection in cystic fibrosis (CF) lung disease causes airway
neutrophilia and hyperinflammation without effective bacterial clearance. We evaluated the …

Pseudomonas aeruginosa (PA) is a ubiquitous environmental Gram-negative bacterium
found in soil and water. This opportunistic pathogen can cause infections in individuals with …

The main cause of the high morbidity and mortality of cystic fibrosis (CF) is the progressive
lung inflammation associated with Pseudomonas aeruginosa colonization. During the …

Lipopolysaccharide (LPS) is the major surface component of gram-negative bacteria, and a
component of LPS, lipid A, is recognized by the innate immune system through the Toll-like …

Pseudomonas aeruginosa can survive in a myriad of environments, partially due to
modifications of its lipid A, the membrane anchor of lipopolysaccharide. We previously …

Pseudomonas aeruginosa (Pa) is a pathogen causing chronic pulmonary infections in
patients with cystic fibrosis (CF). Manipulation of lipids is an important feature of Pa infection …