Cigarette smoke induced lung barrier dysfunction, EMT, and tissue remodeling: a possible link between COPD and lung cancer

W Hou, S Hu, C Li, H Ma, Q Wang… - BioMed research …, 2019 - Wiley Online Library
Chronic obstructive pulmonary disease (COPD) and lung cancer, closely related to smoking,
are major lung diseases affecting millions of individuals worldwide. The generated gas …

Current concepts on the role of inflammation in COPD and lung cancer

H Yao, I Rahman - Current opinion in pharmacology, 2009 - Elsevier
Chronic obstructive pulmonary disease (COPD) and lung cancer are leading cause of death,
and both are associated with cigarette smoke exposure. It has been shown that 50–70% of …

The role of smoking in the mechanisms of development of chronic obstructive pulmonary disease and atherosclerosis

S Kotlyarov - International Journal of Molecular Sciences, 2023 - mdpi.com
Tobacco smoking is a major cause of chronic obstructive pulmonary disease (COPD) and
atherosclerotic cardiovascular disease (ASCVD). These diseases share common …

Pulmonary epithelium, cigarette smoke, and chronic obstructive pulmonary disease

AJ Thorley, TD Tetley - International journal of chronic obstructive …, 2007 - Taylor & Francis
Chronic obstructive pulmonary disease (COPD) is a complex chronic inflammatory disease
involving a wide variety of cells and inflammatory mediators. The most important etiological …

The effects of epithelial–mesenchymal transitions in COPD induced by cigarette smoke: an update

X Su, W Wu, Z Zhu, X Lin, Y Zeng - Respiratory research, 2022 - Springer
Cigarette smoke is a complex aerosol containing a large number of compounds with a
variety of toxicity and carcinogenicity. Long-term exposure to cigarette smoke significantly …

Chronic obstructive pulmonary disease and lung cancer: new molecular insights

IM Adcock, G Caramori, PJ Barnes - Respiration, 2011 - karger.com
Both chronic obstructive pulmonary disease (COPD) and lung cancer are major causes of
death worldwide. In most cases this reflects cigarette smoke exposure which is able to …

Common pathogenic mechanisms and pathways in the development of COPD and lung cancer

IA Yang, V Relan, CM Wright… - Expert opinion on …, 2011 - Taylor & Francis
Introduction: Lung cancer and COPD commonly coexist in smokers, and the presence of
COPD increases the risk of developing lung cancer. In addition to smoking cessation and …

Pathobiology of cigarette smoke-induced chronic obstructive pulmonary disease

T Yoshida, RM Tuder - Physiological reviews, 2007 - journals.physiology.org
Chronic obstructive pulmonary diseases (COPD), comprised of pulmonary emphysema,
chronic bronchitis, and structural and inflammatory changes of small airways, is a leading …

Interrelated role of cigarette smoking, oxidative stress, and immune response in COPD and corresponding treatments

L Zuo, F He, GG Sergakis… - … of Physiology-Lung …, 2014 - journals.physiology.org
Cigarette smoking (CS) can impact the immune system and induce pulmonary disorders
such as chronic obstructive pulmonary disease (COPD), which is currently the fourth leading …

Airway epithelial barrier dysfunction in chronic obstructive pulmonary disease: role of cigarette smoke exposure

M Aghapour, P Raee, SJ Moghaddam… - American journal of …, 2018 - atsjournals.org
The epithelial lining of the airway forms the first barrier against environmental insults, such
as inhaled cigarette smoke, which is the primary risk factor for the development of chronic …