It is widely accepted that senescent cells accumulate with aging. They are characterized by
replicative arrest and the release of a myriad of factors commonly called the senescence …

Cellular senescence suppresses cancer by preventing the proliferation of cells that
experience potentially oncogenic stimuli. Senescent cells often express p16 INK4a, a cyclin …

Cellular senescence, triggered by sublethal damage, is characterized by indefinite growth
arrest, altered gene expression patterns, and a senescence-associated secretory …

Many cellular stresses activate senescence, a persistent hyporeplicative state characterized
in part by expression of the p16 INK4a cell-cycle inhibitor. Senescent cell production occurs …

Aging is a biological feature that is characterized by gradual degeneration of function in
cells, tissues, organs, or an intact organism due to the accumulation of environmental factors …

Cellular senescence is a state of irreversible cellular growth arrest accompanied by distinct
changes in gene expression and the acquisition of a complex proinflammatory secretory …

Cyclin-dependent kinase inhibitors p16INK4a, p21Cip1, and p27Kip1 are regarded as key
effectors of cellular senescence. In this review, we describe three senescence-inducing …

Cellular senescence is a state of permanent growth arrest and is thought to play a pivotal
role in tumor suppression. Cellular senescence may play an important role in tumor …

The Ink4a/Arf locus encodes 2 tumor suppressor molecules, p16INK4a and Arf, which are
principal mediators of cellular senescence. To study the links between senescence and …

Cellular senescence is an established cellular stress response that acts primarily to prevent
the proliferation of cells that experience potentially oncogenic stress. In recent years, it has …