Negative regulation of neuroblastoma cell growth by carbohydrate-dependent surface binding of galectin-1 and functional divergence from galectin-3
J Kopitz, C von Reitzenstein, S André, H Kaltner… - Journal of Biological …, 2001 - ASBMB
The cell density-dependent growth inhibition of human SK-N-MC neuroblastoma cells is
initiated by increased ganglioside sialidase activity leading to elevated cell surface …
initiated by increased ganglioside sialidase activity leading to elevated cell surface …
Homodimeric galectin-7 (p53-induced gene 1) is a negative growth regulator for human neuroblastoma cells
J Kopitz, S Andre, C Von Reitzenstein, K Versluis… - Oncogene, 2003 - nature.com
The extracellular functions of galectin-7 (p53-induced gene 1) are largely unknown. On the
surface of neuroblastoma cells (SK-N-MC), the increased GM 1 density, a result of …
surface of neuroblastoma cells (SK-N-MC), the increased GM 1 density, a result of …
Galectin-1 is a major receptor for ganglioside GM1, a product of the growth-controlling activity of a cell surface ganglioside sialidase, on human neuroblastoma cells in …
J Kopitz, C von Reitzenstein, M Burchert… - Journal of Biological …, 1998 - ASBMB
Cell density-dependent inhibition of growth and neural differentiation in the human
neuroblastoma cell line SK-N-MC are associated with a ganglioside sialidase-mediated …
neuroblastoma cell line SK-N-MC are associated with a ganglioside sialidase-mediated …
How adhesion/growth‐regulatory galectins‐1 and‐3 attain cell specificity: case study defining their target on neuroblastoma cells (SK‐N‐MC) and marked affinity …
J Kopitz, M Bergmann, HJ Gabius - Iubmb Life, 2010 - Wiley Online Library
Galectins are potent effectors with conspicuous cell‐type‐specific activity profile. Its
occurrence poses the question on the nature of the underlying biochemical determinants, in …
occurrence poses the question on the nature of the underlying biochemical determinants, in …
Galectin-1 modulates human glioblastoma cell migration into the brain through modifications to the actin cytoskeleton and levels of expression of small GTPases
I Camby, N Belot, F Lefranc, N Sadeghi… - … of Neuropathology & …, 2002 - academic.oup.com
We show that high-grade astrocytic tumors with high levels of galectin-1 expression are
associated with dismal prognoses. The immunohistochemical analysis of galectin-1 …
associated with dismal prognoses. The immunohistochemical analysis of galectin-1 …
Galectin‐1 is highly expressed in human gliomas with relevance for modulation of invasion of tumor astrocytes into the brain parenchyma
S Rorive, N Belot, C Decaestecker, F Lefranc… - Glia, 2001 - Wiley Online Library
Protein (lectin)‐carbohydrate interaction is supposed to be relevant for tumor cell behavior.
The aims of the present work are to investigate whether galectin‐1 modulates …
The aims of the present work are to investigate whether galectin‐1 modulates …
Galectin-3 stimulates cell proliferation
H Inohara, S Akahani, A Raz - Experimental cell research, 1998 - Elsevier
Galectin-3, a β-galactoside-binding protein, has been shown to be involved in multiple
biological processes through interaction with its complementary glycoconjugates. Here we …
biological processes through interaction with its complementary glycoconjugates. Here we …
Human chimera-type galectin-3: defining the critical tail length for high-affinity glycoprotein/cell surface binding and functional competition with galectin-1 in …
J Kopitz, S Vértesy, S André, S Fiedler, M Schnölzer… - Biochimie, 2014 - Elsevier
Many human proteins have a modular design with receptor and structural domains. Using
adhesion/growth-regulatory galectin-3 as model, we describe an interdisciplinary strategy to …
adhesion/growth-regulatory galectin-3 as model, we describe an interdisciplinary strategy to …
Expression of galectin‐1 mRNA correlates with the malignant potential of human gliomas and expression of antisense galectin‐1 inhibits the growth of 9 glioma cells
K Yamaoka, K Mishima, Y Nagashima… - Journal of …, 2000 - Wiley Online Library
Although its precise function has not yet been established, galectin‐1 seems to play a role in
tumor progression. In this study, we investigated galectin‐1 mRNA expression in human …
tumor progression. In this study, we investigated galectin‐1 mRNA expression in human …
Galectin-1 knocking down in human U87 glioblastoma cells alters their gene expression pattern
I Camby, C Decaestecker, F Lefranc, H Kaltner… - Biochemical and …, 2005 - Elsevier
We have previously reported that (i) progression of malignancy in patients bearing astrocytic
tumors correlates with increased tumor levels of galectin-1;(ii) in vitro addition of purified …
tumors correlates with increased tumor levels of galectin-1;(ii) in vitro addition of purified …
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