Specific binding of either soluble Fas ligand extracellular domain (sFasL) or agonistic anti-
Fas receptor extracellular-domain monoclonal-antibodies (FasR-mAb) can trigger apoptotic …

About a decade ago, the death factor Fas ligand (FasL) was identified as the natural trigger
of Fas/CD95-dependent apoptosis and as an inducer of Fas-dependent activation-induced …

Fas antigen (Fas) is a cell surface receptor molecule introducing apoptosis-inducing signals
into Fas-bearing cells by stimulation with Fas ligand or agonistic anti-Fas monoclonal …

Apoptosis mediated by the Fas/FasL pair of receptor and ligand is involved in physiological
or pathological processes in which cell death is either required to eliminate potentially …

We have produced three forms of human Fas: full‐length Fas, Fas with a C‐terminal
deletion, and a chimera between extracellular Fas and the intracellular domain of the tumor …

The TNF family member Fas ligand (FasL) induces apoptosis in Fas-expressing cells and
serves as a key death factor in the immune system. It is involved in the termination of …

Receptor agonism remains poorly understood at the molecular and mechanistic level. In this
study, we identified a fully human anti-Fas antibody that could efficiently trigger apoptosis …

Fas–Fas-ligand, the most well investigated apoptotic signaling system, plays a pivotal role in
several human diseases. Its signaling through multiple pathways; multiple, complex …

Activation‐induced cell death (AICD) is the process by which cells undergo apoptosis in a
controlled manner through the interaction of a death factor and its receptor. Programmed cell …

Interactions between the TNF-family receptor Fas (CD95) and Fas Ligand (FasL, CD178)
can efficiently induce apoptosis and are critical for the maintenance of immunological self …